# Performance Assessment Strategies for Language Model Applications in Healthcare

arXiv: https://arxiv.org/abs/2509.08087 · HTML: https://mlsanity.com/paper/2509.08087/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 30 of its 59 references that are in the map.
- First posted on arXiv 9 Sep 2025.

## Builds on (most cited first, 30 of 30)

- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [GLUE: A Multi-Task Benchmark and Analysis Platform for Natural Language Understanding](https://mlsanity.com/paper/1804.07461/) (2018)
- [G-Eval: NLG Evaluation using GPT-4 with Better Human Alignment](https://mlsanity.com/paper/2303.16634/) (2023)
- [A Survey on LLM-as-a-Judge](https://mlsanity.com/paper/2411.15594/) (2024)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [Can Large Language Models Be an Alternative to Human Evaluations?](https://mlsanity.com/paper/2305.01937/) (2023)
- [From Generation to Judgment: Opportunities and Challenges of LLM-as-a-judge](https://mlsanity.com/paper/2411.16594/) (2024)
- [LLMs-as-Judges: A Comprehensive Survey on LLM-based Evaluation Methods](https://mlsanity.com/paper/2412.05579/) (2024)
- [HealthBench: Evaluating Large Language Models Towards Improved Human Health](https://mlsanity.com/paper/2505.08775/) (2025)
- [NLP Evaluation in trouble: On the Need to Measure LLM Data Contamination for each Benchmark](https://mlsanity.com/paper/2310.18018/) (2023)
- [Replacing Judges with Juries: Evaluating LLM Generations with a Panel of Diverse Models](https://mlsanity.com/paper/2404.18796/) (2024)
- [Towards Generalist Biomedical AI](https://mlsanity.com/paper/2307.14334/) (2023)
- [Adapted Large Language Models Can Outperform Medical Experts in Clinical Text Summarization](https://mlsanity.com/paper/2309.07430/) (2023)
- [AgentClinic: a multimodal agent benchmark to evaluate AI in simulated clinical environments](https://mlsanity.com/paper/2405.07960/) (2024)
- [BiomedGPT: A Generalist Vision-Language Foundation Model for Diverse Biomedical Tasks](https://mlsanity.com/paper/2305.17100/) (2023)
- [GREEN: Generative Radiology Report Evaluation and Error Notation](https://mlsanity.com/paper/2405.03595/) (2024)
- [Segment Anything Model for Medical Image Segmentation: Current Applications and Future Directions](https://mlsanity.com/paper/2401.03495/) (2024)
- [Advancing Multimodal Medical Capabilities of Gemini](https://mlsanity.com/paper/2405.03162/) (2024)
- [Planning, Creation, Usage: Benchmarking LLMs for Comprehensive Tool Utilization in Real-World Complex Scenarios](https://mlsanity.com/paper/2401.17167/) (2024)
- [MedHELM: Holistic Evaluation of Large Language Models for Medical Tasks](https://mlsanity.com/paper/2505.23802/) (2025)
- [Sequential Diagnosis with Language Models](https://mlsanity.com/paper/2506.22405/) (2025)
- [Top Leaderboard Ranking = Top Coding Proficiency, Always? EvoEval: Evolving Coding Benchmarks via LLM](https://mlsanity.com/paper/2403.19114/) (2024)
- [Examining the robustness of LLM evaluation to the distributional assumptions of benchmarks](https://mlsanity.com/paper/2404.16966/) (2024)
- [Adaptive Preference Scaling for Reinforcement Learning with Human Feedback](https://mlsanity.com/paper/2406.02764/) (2024)
- [ReXVQA: A Large-scale Visual Question Answering Benchmark for Generalist Chest X-ray Understanding](https://mlsanity.com/paper/2506.04353/) (2025)
- [Large Language Model Benchmarks in Medical Tasks](https://mlsanity.com/paper/2410.21348/) (2024)
- [VeriFact: Verifying Facts in LLM-Generated Clinical Text with Electronic Health Records](https://mlsanity.com/paper/2501.16672/) (2025)
- [Benchmark datasets driving artificial intelligence development fail to capture the needs of medical professionals](https://mlsanity.com/paper/2201.07040/) (2022)
- [LLM-RadJudge: Achieving Radiologist-Level Evaluation for X-Ray Report Generation](https://mlsanity.com/paper/2404.00998/) (2024)
- [Synthetic Data in Radiological Imaging: Current State and Future Outlook](https://mlsanity.com/paper/2407.01561/) (2024)

## Abstract (arXiv)

Language models (LMs) represent an emerging paradigm within artificial intelligence, with applications throughout the medical enterprise. A comprehensive understanding of the clinical task and awareness of the variability in performance when implemented in actual clinical environments lays the foundation for the LM application assessment. Presently, a prevalent method for evaluating the performance of these generative models relies on quantitative benchmarks. Such benchmarks have limitations and may suffer from train-to-the-test overfitting, optimizing performance for a specified test set at the cost of generalizability across other tasks and data distributions. Evaluation strategies leveraging human expertise and utilizing cost-effective computational models as evaluators are gaining interest. We discuss current state-of-the-art methodologies for assessing the performance of LM applications in healthcare and medical devices.