# Contrastive Anatomy-Contrast Disentanglement: A Domain-General MRI Harmonization Method

arXiv: https://arxiv.org/abs/2509.06592 · HTML: https://mlsanity.com/paper/2509.06592/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 33 references that are in the map.
- First posted on arXiv 8 Sep 2025.

## Builds on (most cited first, 15 of 15)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [Diffusion Autoencoders: Toward a Meaningful and Decodable Representation](https://mlsanity.com/paper/2111.15640/) (2021)
- [Diffusion Models for Medical Anomaly Detection](https://mlsanity.com/paper/2203.04306/) (2022)
- [Unsupervised Medical Image Translation with Adversarial Diffusion Models](https://mlsanity.com/paper/2207.08208/) (2022)
- [Causality-inspired Single-source Domain Generalization for Medical Image Segmentation](https://mlsanity.com/paper/2111.12525/) (2021)
- [WDM: 3D Wavelet Diffusion Models for High-Resolution Medical Image Synthesis](https://mlsanity.com/paper/2402.19043/) (2024)
- [Joint super-resolution and synthesis of 1 mm isotropic MP-RAGE volumes from clinical MRI exams with scans of different orientation, resolution and contrast](https://mlsanity.com/paper/2012.13340/) (2020)
- [Devil is in Channels: Contrastive Single Domain Generalization for Medical Image Segmentation](https://mlsanity.com/paper/2306.05254/) (2023)
- [CDDSA: Contrastive Domain Disentanglement and Style Augmentation for Generalizable Medical Image Segmentation](https://mlsanity.com/paper/2211.12081/) (2022)
- [HACA3: A Unified Approach for Multi-site MR Image Harmonization](https://mlsanity.com/paper/2212.06065/) (2022)
- [ImUnity: a generalizable VAE-GAN solution for multicenter MR image harmonization](https://mlsanity.com/paper/2109.06756/) (2021)
- [Disentangling A Single MR Modality](https://mlsanity.com/paper/2205.04982/) (2022)

## Built on by (most cited first, 1 of 1)

- [A Target-Free Harmonization Method for MRI](https://mlsanity.com/paper/2605.01282/) (2026)

## Abstract (arXiv)

Magnetic resonance imaging (MRI) is an invaluable tool for clinical and research applications. Yet, variations in scanners and acquisition parameters cause inconsistencies in image contrast, hindering data comparability and reproducibility across datasets and clinical studies. Existing scanner harmonization methods, designed to address this challenge, face limitations, such as requiring traveling subjects or struggling to generalize to unseen domains. We propose a novel approach using a conditioned diffusion autoencoder with a contrastive loss and domain-agnostic contrast augmentation to harmonize MR images across scanners while preserving subject-specific anatomy. Our method enables brain MRI synthesis from a single reference image. It outperforms baseline techniques, achieving a +7% PSNR improvement on a traveling subjects dataset and +18% improvement on age regression in unseen. Our model provides robust, effective harmonization of brain MRIs to target scanners without requiring fine-tuning. This advancement promises to enhance comparability, reproducibility, and generalizability in multi-site and longitudinal clinical studies, ultimately contributing to improved healthcare outcomes.