# The Physical Basis of Prediction: World Model Formation in Neural Organoids via an LLM-Generated Curriculum

arXiv: https://arxiv.org/abs/2509.04633 · HTML: https://mlsanity.com/paper/2509.04633/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in World models for navigation, one of 11 directions in World models.
- Builds on 2 of its 34 references that are in the map.
- First posted on arXiv 4 Sep 2025.

## Placed in

- World models / [World models for navigation](https://mlsanity.com/wm/world-models-for-navigation/)

## Builds on (most cited first, 2 of 2)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [The Free Energy Principle for Perception and Action: A Deep Learning Perspective](https://mlsanity.com/paper/2207.06415/) (2022)

## Abstract (arXiv)

The capacity of an embodied agent to understand, predict, and interact with its environment is fundamentally contingent on an internal world model. This paper introduces a novel framework for investigating the formation and adaptation of such world models within a biological substrate: human neural organoids. We present a curriculum of three scalable, closed-loop virtual environments designed to train these biological agents and probe the underlying synaptic mechanisms of learning, such as long-term potentiation (LTP) and long-term depression (LTD). We detail the design of three distinct task environments that demand progressively more sophisticated world models for successful decision-making: (1) a conditional avoidance task for learning static state-action contingencies, (2) a one-dimensional predator-prey scenario for goal-directed interaction, and (3) a replication of the classic Pong game for modeling dynamic, continuous-time systems. For each environment, we formalize the state and action spaces, the sensory encoding and motor decoding mechanisms, and the feedback protocols based on predictable (reward) and unpredictable (punishment) stimulation, which serve to drive model refinement. In a significant methodological advance, we propose a meta-learning approach where a Large Language Model automates the generative design and optimization of experimental protocols, thereby scaling the process of environment and curriculum design. Finally, we outline a multi-modal evaluation strategy that moves beyond task performance to directly measure the physical correlates of the learned world model by quantifying synaptic plasticity at electrophysiological, cellular, and molecular levels. This work bridges the gap between model-based reinforcement learning and computational neuroscience, offering a unique platform for studying embodiment, decision-making, and the physical basis of intelligence.