# Synthetic Survival Data Generation for Heart Failure Prognosis Using Deep Generative Models

arXiv: https://arxiv.org/abs/2509.04245 · HTML: https://mlsanity.com/paper/2509.04245/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 56 references that are in the map.
- First posted on arXiv 4 Sep 2025.

## Builds on (most cited first, 9 of 9)

- [Modeling Tabular data using Conditional GAN](https://mlsanity.com/paper/1907.00503/) (2019)
- [Neural Spline Flows](https://mlsanity.com/paper/1906.04032/) (2019)
- [DeepSurv: Personalized Treatment Recommender System Using A Cox Proportional Hazards Deep Neural Network](https://mlsanity.com/paper/1606.00931/) (2016)
- [Time-to-Event Prediction with Neural Networks and Cox Regression](https://mlsanity.com/paper/1907.00825/) (2019)
- [HyperImpute: Generalized Iterative Imputation with Automatic Model Selection](https://mlsanity.com/paper/2206.07769/) (2022)
- [Synthcity: facilitating innovative use cases of synthetic data in different data modalities](https://mlsanity.com/paper/2301.07573/) (2023)
- [A Multifaceted Benchmarking of Synthetic Electronic Health Record Generation Models](https://mlsanity.com/paper/2208.01230/) (2022)
- [Synthetic Data in Human Analysis: A Survey](https://mlsanity.com/paper/2208.09191/) (2022)
- [SurvivalGAN: Generating Time-to-Event Data for Survival Analysis](https://mlsanity.com/paper/2302.12749/) (2023)

## Abstract (arXiv)

Background: Heart failure (HF) research is constrained by limited access to large, shareable datasets due to privacy regulations and institutional barriers. Synthetic data generation offers a promising solution to overcome these challenges while preserving patient confidentiality. Methods: We generated synthetic HF datasets from institutional data comprising 12,552 unique patients using five deep learning models: tabular variational autoencoder (TVAE), normalizing flow, ADSGAN, SurvivalGAN, and tabular denoising diffusion probabilistic models (TabDDPM). We comprehensively evaluated synthetic data utility through statistical similarity metrics, survival prediction using machine learning and privacy assessments. Results: SurvivalGAN and TabDDPM demonstrated high fidelity to the original dataset, exhibiting similar variable distributions and survival curves after applying histogram equalization. SurvivalGAN (C-indices: 0.71-0.76) and TVAE (C-indices: 0.73-0.76) achieved the strongest performance in survival prediction evaluation, closely matched real data performance (C-indices: 0.73-0.76). Privacy evaluation confirmed protection against re-identification attacks. Conclusions: Deep learning-based synthetic data generation can produce high-fidelity, privacy-preserving HF datasets suitable for research applications. This publicly available synthetic dataset addresses critical data sharing barriers and provides a valuable resource for advancing HF research and predictive modeling.