# Heatmap Guided Query Transformers for Robust Astrocyte Detection across Immunostains and Resolutions

arXiv: https://arxiv.org/abs/2509.03323 · HTML: https://mlsanity.com/paper/2509.03323/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 14 of its 29 references that are in the map.
- First posted on arXiv 3 Sep 2025.

## Builds on (most cited first, 14 of 14)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Faster R-CNN: Towards Real-Time Object Detection with Region Proposal Networks](https://mlsanity.com/paper/1506.01497/) (2015)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [Feature Pyramid Networks for Object Detection](https://mlsanity.com/paper/1612.03144/) (2016)
- [Deformable DETR: Deformable Transformers for End-to-End Object Detection](https://mlsanity.com/paper/2010.04159/) (2020)
- [Generalized Intersection over Union: A Metric and A Loss for Bounding Box Regression](https://mlsanity.com/paper/1902.09630/) (2019)
- [CenterNet: Keypoint Triplets for Object Detection](https://mlsanity.com/paper/1904.08189/) (2019)
- [DAB-DETR: Dynamic Anchor Boxes are Better Queries for DETR](https://mlsanity.com/paper/2201.12329/) (2022)
- [Distance-IoU Loss: Faster and Better Learning for Bounding Box Regression](https://mlsanity.com/paper/1911.08287/) (2019)
- [Soft-NMS -- Improving Object Detection With One Line of Code](https://mlsanity.com/paper/1704.04503/) (2017)
- [RT-DETRv3: Real-time End-to-End Object Detection with Hierarchical Dense Positive Supervision](https://mlsanity.com/paper/2409.08475/) (2024)
- [Taming Detection Transformers for Medical Object Detection](https://mlsanity.com/paper/2306.15472/) (2023)

## Abstract (arXiv)

Astrocytes are critical glial cells whose altered morphology and density are hallmarks of many neurological disorders. However, their intricate branching and stain dependent variability make automated detection of histological images a highly challenging task. To address these challenges, we propose a hybrid CNN Transformer detector that combines local feature extraction with global contextual reasoning. A heatmap guided query mechanism generates spatially grounded anchors for small and faint astrocytes, while a lightweight Transformer module improves discrimination in dense clusters. Evaluated on ALDH1L1 and GFAP stained astrocyte datasets, the model consistently outperformed Faster R-CNN, YOLOv11 and DETR, achieving higher sensitivity with fewer false positives, as confirmed by FROC analysis. These results highlight the potential of hybrid CNN Transformer architectures for robust astrocyte detection and provide a foundation for advanced computational pathology tools.