# Mix-modal Federated Learning for MRI Image Segmentation

arXiv: https://arxiv.org/abs/2509.02541 · HTML: https://mlsanity.com/paper/2509.02541/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 17 of its 37 references that are in the map.
- First posted on arXiv 2 Sep 2025.

## Builds on (most cited first, 17 of 17)

- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Federated Optimization in Heterogeneous Networks](https://mlsanity.com/paper/1812.06127/) (2018)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [Opening the Black Box of Deep Neural Networks via Information](https://mlsanity.com/paper/1703.00810/) (2017)
- [The ASNR-MICCAI Brain Tumor Segmentation (BraTS) Challenge 2023: Intracranial Meningioma](https://mlsanity.com/paper/2305.07642/) (2023)
- [FedDiff: Diffusion Model Driven Federated Learning for Multi-Modal and Multi-Clients](https://mlsanity.com/paper/2401.02433/) (2023)
- [IOP-FL: Inside-Outside Personalization for Federated Medical Image Segmentation](https://mlsanity.com/paper/2204.08467/) (2022)
- [Cross-Modal Prototype based Multimodal Federated Learning under Severely Missing Modality](https://mlsanity.com/paper/2401.13898/) (2024)
- [Multimodal CNN Networks for Brain Tumor Segmentation in MRI: A BraTS 2022 Challenge Solution](https://mlsanity.com/paper/2212.09310/) (2022)
- [ADMarker: A Multi-Modal Federated Learning System for Monitoring Digital Biomarkers of Alzheimer's Disease](https://mlsanity.com/paper/2310.15301/) (2023)
- [FedA3I: Annotation Quality-Aware Aggregation for Federated Medical Image Segmentation against Heterogeneous Annotation Noise](https://mlsanity.com/paper/2312.12838/) (2023)
- [Federated Modality-specific Encoders and Multimodal Anchors for Personalized Brain Tumor Segmentation](https://mlsanity.com/paper/2403.11803/) (2024)
- [TransBTSV2: Towards Better and More Efficient Volumetric Segmentation of Medical Images](https://mlsanity.com/paper/2201.12785/) (2022)
- [Adaptive Aggregation Weights for Federated Segmentation of Pancreas MRI](https://mlsanity.com/paper/2410.22530/) (2024)
- [MedMAP: Promoting Incomplete Multi-modal Brain Tumor Segmentation with Alignment](https://mlsanity.com/paper/2408.09465/) (2024)
- [Federated Client-tailored Adapter for Medical Image Segmentation](https://mlsanity.com/paper/2504.18020/) (2025)

## Abstract (arXiv)

Magnetic resonance imaging (MRI) image segmentation is crucial in diagnosing and treating many diseases, such as brain tumors. Existing MRI image segmentation methods mainly fall into a centralized multimodal paradigm, which is inapplicable in engineering non-centralized mix-modal medical scenarios. In this situation, each distributed client (hospital) processes multiple mixed MRI modalities, and the modality set and image data for each client are diverse, suffering from extensive client-wise modality heterogeneity and data heterogeneity. In this paper, we first formulate non-centralized mix-modal MRI image segmentation as a new paradigm for federated learning (FL) that involves multiple modalities, called mix-modal federated learning (MixMFL). It distinguishes from existing multimodal federating learning (MulMFL) and cross-modal federating learning (CroMFL) paradigms. Then, we proposed a novel modality decoupling and memorizing mix-modal federated learning framework (MDM-MixMFL) for MRI image segmentation, which is characterized by a modality decoupling strategy and a modality memorizing mechanism. Specifically, the modality decoupling strategy disentangles each modality into modality-tailored and modality-shared information. During mix-modal federated updating, corresponding modality encoders undergo tailored and shared updating, respectively. It facilitates stable and adaptive federating aggregation of heterogeneous data and modalities from distributed clients. Besides, the modality memorizing mechanism stores client-shared modality prototypes dynamically refreshed from every modality-tailored encoder to compensate for incomplete modalities in each local client.