# LVLM-Aware Multimodal Retrieval for RAG-Based Medical Diagnosis with General-Purpose Models

arXiv: https://arxiv.org/abs/2508.17394 · HTML: https://mlsanity.com/paper/2508.17394/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 21 of its 36 references that are in the map.
- First posted on arXiv 24 Aug 2025.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)

## Builds on (most cited first, 21 of 21)

- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Qwen2-VL: Enhancing Vision-Language Model's Perception of the World at Any Resolution](https://mlsanity.com/paper/2409.12191/) (2024)
- [Billion-scale similarity search with GPUs](https://mlsanity.com/paper/1702.08734/) (2017)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Leveraging Passage Retrieval with Generative Models for Open Domain Question Answering](https://mlsanity.com/paper/2007.01282/) (2020)
- [Atlas: Few-shot Learning with Retrieval Augmented Language Models](https://mlsanity.com/paper/2208.03299/) (2022)
- [REPLUG: Retrieval-Augmented Black-Box Language Models](https://mlsanity.com/paper/2301.12652/) (2023)
- [MedMNIST v2 -- A large-scale lightweight benchmark for 2D and 3D biomedical image classification](https://mlsanity.com/paper/2110.14795/) (2021)
- [PathVQA: 30000+ Questions for Medical Visual Question Answering](https://mlsanity.com/paper/2003.10286/) (2020)
- [SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answering](https://mlsanity.com/paper/2102.09542/) (2021)
- [Med-Flamingo: a Multimodal Medical Few-shot Learner](https://mlsanity.com/paper/2307.15189/) (2023)
- [Making Retrieval-Augmented Language Models Robust to Irrelevant Context](https://mlsanity.com/paper/2310.01558/) (2023)
- [PMC-CLIP: Contrastive Language-Image Pre-training using Biomedical Documents](https://mlsanity.com/paper/2303.07240/) (2023)
- [RA-DIT: Retrieval-Augmented Dual Instruction Tuning](https://mlsanity.com/paper/2310.01352/) (2023)
- [REVEAL: Retrieval-Augmented Visual-Language Pre-Training with Multi-Source Multimodal Knowledge Memory](https://mlsanity.com/paper/2212.05221/) (2022)
- [BioMedGPT: Open Multimodal Generative Pre-trained Transformer for BioMedicine](https://mlsanity.com/paper/2308.09442/) (2023)
- [Jina CLIP: Your CLIP Model Is Also Your Text Retriever](https://mlsanity.com/paper/2405.20204/) (2024)
- [GSCo: Towards Generalizable AI in Medicine via Generalist-Specialist Collaboration](https://mlsanity.com/paper/2404.15127/) (2024)
- [RAMM: Retrieval-augmented Biomedical Visual Question Answering with Multi-modal Pre-training](https://mlsanity.com/paper/2303.00534/) (2023)
- [SURf: Teaching Large Vision-Language Models to Selectively Utilize Retrieved Information](https://mlsanity.com/paper/2409.14083/) (2024)
- [The Limited Impact of Medical Adaptation of Large Language and Vision-Language Models](https://mlsanity.com/paper/2411.08870/) (2024)

## Abstract (arXiv)

Retrieving visual and textual information from medical literature and hospital records can enhance diagnostic accuracy for clinical image interpretation. However, multimodal retrieval-augmented diagnosis is highly challenging. We explore a lightweight mechanism for enhancing diagnostic performance of retrieval-augmented LVLMs. We train a lightweight LVLM-aware multimodal retriever, such that the retriever learns to return images and texts that guide the LVLM toward correct predictions. In our low-resource setting, we perform only lightweight fine-tuning with small amounts of data, and use only general-purpose backbone models, achieving competitive results in clinical classification and VQA tasks compared to medically pre-trained models with extensive training. In a novel analysis, we highlight a previously unexplored class of errors that we term inconsistent retrieval predictions: cases where different top-retrieved images yield different predictions for the same target. We find that these cases are challenging for all models, even for non-retrieval models, and that our retrieval optimization mechanism significantly improves these cases over standard RAG. However, our analysis also sheds light on gaps in the ability of LVLMs to utilize retrieved information for clinical predictions. Code and models available at: https://github.com/Nirmaz/CLARE.