# Generating Synthetic Contrast-Enhanced Chest CT Images from Non-Contrast Scans Using Slice-Consistent Brownian Bridge Diffusion Network

arXiv: https://arxiv.org/abs/2508.16897 · HTML: https://mlsanity.com/paper/2508.16897/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 4 of its 13 references that are in the map.
- First posted on arXiv 23 Aug 2025.

## Builds on (most cited first, 4 of 4)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [TotalSegmentator: robust segmentation of 104 anatomical structures in CT images](https://mlsanity.com/paper/2208.05868/) (2022)
- [Slice-Consistent 3D Volumetric Brain CT-to-MRI Translation with 2D Brownian Bridge Diffusion Model](https://mlsanity.com/paper/2407.05059/) (2024)

## Built on by (most cited first, 1 of 1)

- [Uncertainty as a Proxy for Semantic Correctness in Diffusion-Based Medical Image Synthesis](https://mlsanity.com/paper/2610.03224/) (2026)

## Abstract (arXiv)

Contrast-enhanced computed tomography (CT) imaging is essential for diagnosing and monitoring thoracic diseases, including aortic pathologies. However, contrast agents pose risks such as nephrotoxicity and allergic-like reactions. The ability to generate high-fidelity synthetic contrast-enhanced CT angiography (CTA) images without contrast administration would be transformative, enhancing patient safety and accessibility while reducing healthcare costs. In this study, we propose the first bridge diffusion-based solution for synthesizing contrast-enhanced CTA images from non-contrast CT scans. Our approach builds on the Slice-Consistent Brownian Bridge Diffusion Model (SC-BBDM), leveraging its ability to model complex mappings while maintaining consistency across slices. Unlike conventional slice-wise synthesis methods, our framework preserves full 3D anatomical integrity while operating in a high-resolution 2D fashion, allowing seamless volumetric interpretation under a low memory budget. To ensure robust spatial alignment, we implement a comprehensive preprocessing pipeline that includes resampling, registration using the Symmetric Normalization method, and a sophisticated dilated segmentation mask to extract the aorta and surrounding structures. We create two datasets from the Coltea-Lung dataset: one containing only the aorta and another including both the aorta and heart, enabling a detailed analysis of anatomical context. We compare our approach against baseline methods on both datasets, demonstrating its effectiveness in preserving vascular structures while enhancing contrast fidelity.