# ReProCon: Scalable and Resource-Efficient Few-Shot Biomedical Named Entity Recognition

arXiv: https://arxiv.org/abs/2508.16833 · HTML: https://mlsanity.com/paper/2508.16833/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 16 of its 32 references that are in the map.
- First posted on arXiv 22 Aug 2025.

## Builds on (most cited first, 16 of 16)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Layer Normalization](https://mlsanity.com/paper/1607.06450/) (2016)
- [SGDR: Stochastic Gradient Descent with Warm Restarts](https://mlsanity.com/paper/1608.03983/) (2016)
- [Model-Agnostic Meta-Learning for Fast Adaptation of Deep Networks](https://mlsanity.com/paper/1703.03400/) (2017)
- [Prototypical Networks for Few-shot Learning](https://mlsanity.com/paper/1703.05175/) (2017)
- [UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction](https://mlsanity.com/paper/1802.03426/) (2018)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Enriching Word Vectors with Subword Information](https://mlsanity.com/paper/1607.04606/) (2016)
- [SciBERT: A Pretrained Language Model for Scientific Text](https://mlsanity.com/paper/1903.10676/) (2019)
- [On First-Order Meta-Learning Algorithms](https://mlsanity.com/paper/1803.02999/) (2018)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [Few-NERD: A Few-Shot Named Entity Recognition Dataset](https://mlsanity.com/paper/2105.07464/) (2021)
- [Decomposed Meta-Learning for Few-Shot Named Entity Recognition](https://mlsanity.com/paper/2204.05751/) (2022)
- [Few-shot Named Entity Recognition with Entity-level Prototypical Network Enhanced by Dispersedly Distributed Prototypes](https://mlsanity.com/paper/2208.08023/) (2022)
- [SpanProto: A Two-stage Span-based Prototypical Network for Few-shot Named Entity Recognition](https://mlsanity.com/paper/2210.09049/) (2022)

## Abstract (arXiv)

Named Entity Recognition (NER) in biomedical domains faces challenges due to data scarcity and imbalanced label distributions, especially with fine-grained entity types. We propose ReProCon, a novel few-shot NER framework that combines multi-prototype modeling, cosine-contrastive learning, and Reptile meta-learning to tackle these issues. By representing each category with multiple prototypes, ReProCon captures semantic variability, such as synonyms and contextual differences, while a cosine-contrastive objective ensures strong interclass separation. Reptile meta-updates enable quick adaptation with little data. Using a lightweight fastText + BiLSTM encoder with much lower memory usage, ReProCon achieves a macro-F1 score close to BERT-based baselines (around 99 percent of BERT performance). The model remains stable with a label budget of 30 percent and only drops 7.8 percent in F1 when expanding from 19 to 50 categories, outperforming baselines such as SpanProto and CONTaiNER, which see 10 to 32 percent degradation in Few-NERD. Ablation studies highlight the importance of multi-prototype modeling and contrastive learning in managing class imbalance. Despite difficulties with label ambiguity, ReProCon demonstrates state-of-the-art performance in resource-limited settings, making it suitable for biomedical applications.