# Normal and Abnormal Pathology Knowledge-Augmented Vision-Language Model for Anomaly Detection in Pathology Images

arXiv: https://arxiv.org/abs/2508.15256 · HTML: https://mlsanity.com/paper/2508.15256/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 33 of its 52 references that are in the map.
- First posted on arXiv 21 Aug 2025.

## Builds on (most cited first, 30 of 33)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Scaling Up Visual and Vision-Language Representation Learning With Noisy Text Supervision](https://mlsanity.com/paper/2102.05918/) (2021)
- [Semantic Image Synthesis with Spatially-Adaptive Normalization](https://mlsanity.com/paper/1903.07291/) (2019)
- [CoCa: Contrastive Captioners are Image-Text Foundation Models](https://mlsanity.com/paper/2205.01917/) (2022)
- [Towards Total Recall in Industrial Anomaly Detection](https://mlsanity.com/paper/2106.08265/) (2021)
- [SimVLM: Simple Visual Language Model Pretraining with Weak Supervision](https://mlsanity.com/paper/2108.10904/) (2021)
- [PaDiM: a Patch Distribution Modeling Framework for Anomaly Detection and Localization](https://mlsanity.com/paper/2011.08785/) (2020)
- [Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery](https://mlsanity.com/paper/1703.05921/) (2017)
- [Anomaly Detection via Reverse Distillation from One-Class Embedding](https://mlsanity.com/paper/2201.10703/) (2022)
- [GANomaly: Semi-Supervised Anomaly Detection via Adversarial Training](https://mlsanity.com/paper/1805.06725/) (2018)
- [Uninformed Students: Student-Teacher Anomaly Detection with Discriminative Latent Embeddings](https://mlsanity.com/paper/1911.02357/) (2019)
- [CFLOW-AD: Real-Time Unsupervised Anomaly Detection with Localization via Conditional Normalizing Flows](https://mlsanity.com/paper/2107.12571/) (2021)
- [WinCLIP: Zero-/Few-Shot Anomaly Classification and Segmentation](https://mlsanity.com/paper/2303.14814/) (2023)
- [Multiresolution Knowledge Distillation for Anomaly Detection](https://mlsanity.com/paper/2011.11108/) (2020)
- [AnomalyCLIP: Object-agnostic Prompt Learning for Zero-shot Anomaly Detection](https://mlsanity.com/paper/2310.18961/) (2023)
- [FastFlow: Unsupervised Anomaly Detection and Localization via 2D Normalizing Flows](https://mlsanity.com/paper/2111.07677/) (2021)
- [Patch SVDD: Patch-level SVDD for Anomaly Detection and Segmentation](https://mlsanity.com/paper/2006.16067/) (2020)
- [Quilt-1M: One Million Image-Text Pairs for Histopathology](https://mlsanity.com/paper/2306.11207/) (2023)
- [EfficientAD: Accurate Visual Anomaly Detection at Millisecond-Level Latencies](https://mlsanity.com/paper/2303.14535/) (2023)
- [Deep Autoencoding Models for Unsupervised Anomaly Segmentation in Brain MR Images](https://mlsanity.com/paper/1804.04488/) (2018)
- [Student-Teacher Feature Pyramid Matching for Anomaly Detection](https://mlsanity.com/paper/2103.04257/) (2021)
- [CFA: Coupled-hypersphere-based Feature Adaptation for Target-Oriented Anomaly Localization](https://mlsanity.com/paper/2206.04325/) (2022)
- [Explainable Deep One-Class Classification](https://mlsanity.com/paper/2007.01760/) (2020)
- [Fully Convolutional Cross-Scale-Flows for Image-based Defect Detection](https://mlsanity.com/paper/2110.02855/) (2021)
- [Asymmetric Student-Teacher Networks for Industrial Anomaly Detection](https://mlsanity.com/paper/2210.07829/) (2022)
- [Modeling the Distribution of Normal Data in Pre-Trained Deep Features for Anomaly Detection](https://mlsanity.com/paper/2005.14140/) (2020)
- [Towards Visually Explaining Variational Autoencoders](https://mlsanity.com/paper/1911.07389/) (2019)
- [Toward Generalist Anomaly Detection via In-context Residual Learning with Few-shot Sample Prompts](https://mlsanity.com/paper/2403.06495/) (2024)
- [Machine learning methods for histopathological image analysis](https://mlsanity.com/paper/1709.00786/) (2017)
- [Fence GAN: Towards Better Anomaly Detection](https://mlsanity.com/paper/1904.01209/) (2019)

## Abstract (arXiv)

Anomaly detection in computational pathology aims to identify rare and scarce anomalies where disease-related data are often limited or missing. Existing anomaly detection methods, primarily designed for industrial settings, face limitations in pathology due to computational constraints, diverse tissue structures, and lack of interpretability. To address these challenges, we propose Ano-NAViLa, a Normal and Abnormal pathology knowledge-augmented Vision-Language model for Anomaly detection in pathology images. Ano-NAViLa is built on a pre-trained vision-language model with a lightweight trainable MLP. By incorporating both normal and abnormal pathology knowledge, Ano-NAViLa enhances accuracy and robustness to variability in pathology images and provides interpretability through image-text associations. Evaluated on two lymph node datasets from different organs, Ano-NAViLa achieves the state-of-the-art performance in anomaly detection and localization, outperforming competing models.