# The Promise of Large Language Models in Digital Health: Evidence from Sentiment Analysis in Online Health Communities

arXiv: https://arxiv.org/abs/2508.14032 · HTML: https://mlsanity.com/paper/2508.14032/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 43 references that are in the map.
- First posted on arXiv 19 Aug 2025.

## Builds on (most cited first, 13 of 13)

- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [A Survey on Evaluation of Large Language Models](https://mlsanity.com/paper/2307.03109/) (2023)
- [ChatGPT Outperforms Crowd-Workers for Text-Annotation Tasks](https://mlsanity.com/paper/2303.15056/) (2023)
- [Evaluation: from precision, recall and F-measure to ROC, informedness, markedness and correlation](https://mlsanity.com/paper/2010.16061/) (2020)
- [SemEval-2017 Task 4: Sentiment Analysis in Twitter](https://mlsanity.com/paper/1912.00741/) (2019)
- [Can ChatGPT Understand Too? A Comparative Study on ChatGPT and Fine-tuned BERT](https://mlsanity.com/paper/2302.10198/) (2023)
- [Relying on the Unreliable: The Impact of Language Models' Reluctance to Express Uncertainty](https://mlsanity.com/paper/2401.06730/) (2024)
- [Can Unconfident LLM Annotations Be Used for Confident Conclusions?](https://mlsanity.com/paper/2408.15204/) (2024)
- [A Wide Evaluation of ChatGPT on Affective Computing Tasks](https://mlsanity.com/paper/2308.13911/) (2023)
- [Natural Language Processing in Electronic Health Records in Relation to Healthcare Decision-making: A Systematic Review](https://mlsanity.com/paper/2306.12834/) (2023)
- [Leveraging ChatGPT As Text Annotation Tool For Sentiment Analysis](https://mlsanity.com/paper/2306.17177/) (2023)
- [Sentiment Analysis of Covid-19 Tweets using Evolutionary Classification-Based LSTM Model](https://mlsanity.com/paper/2106.06910/) (2021)

## Abstract (arXiv)

Digital health analytics face critical challenges nowadays. The sophisticated analysis of patient-generated health content, which contains complex emotional and medical contexts, requires scarce domain expertise, while traditional ML approaches are constrained by data shortage and privacy limitations in healthcare settings. Online Health Communities (OHCs) exemplify these challenges with mixed-sentiment posts, clinical terminology, and implicit emotional expressions that demand specialised knowledge for accurate Sentiment Analysis (SA). To address these challenges, this study explores how Large Language Models (LLMs) can integrate expert knowledge through in-context learning for SA, providing a scalable solution for sophisticated health data analysis. Specifically, we develop a structured codebook that systematically encodes expert interpretation guidelines, enabling LLMs to apply domain-specific knowledge through targeted prompting rather than extensive training. Six GPT models validated alongside DeepSeek and LLaMA 3.1 are compared with pre-trained language models (BioBERT variants) and lexicon-based methods, using 400 expert-annotated posts from two OHCs. LLMs achieve superior performance while demonstrating expert-level agreement. This high agreement, with no statistically significant difference from inter-expert agreement levels, suggests knowledge integration beyond surface-level pattern recognition. The consistent performance across diverse LLM models, supported by in-context learning, offers a promising solution for digital health analytics. This approach addresses the critical challenge of expert knowledge shortage in digital health research, enabling real-time, expert-quality analysis for patient monitoring, intervention assessment, and evidence-based health strategies.