# MME-SCI: A Comprehensive and Challenging Science Benchmark for Multimodal Large Language Models

arXiv: https://arxiv.org/abs/2508.13938 · HTML: https://mlsanity.com/paper/2508.13938/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Placed in MLLM training and visual instruction tuning, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 31 of its 40 references that are in the map.
- First posted on arXiv 19 Aug 2025.

## Placed in

- Multimodal LLMs / vision-language models / [MLLM training and visual instruction tuning](https://mlsanity.com/mllm/mllm-training-and-visual-instruction-tuning/)

## Builds on (most cited first, 30 of 31)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Qwen2.5-VL Technical Report](https://mlsanity.com/paper/2502.13923/) (2025)
- [Qwen2-VL: Enhancing Vision-Language Model's Perception of the World at Any Resolution](https://mlsanity.com/paper/2409.12191/) (2024)
- [Qwen Technical Report](https://mlsanity.com/paper/2309.16609/) (2023)
- [LLaVA-OneVision: Easy Visual Task Transfer](https://mlsanity.com/paper/2408.03326/) (2024)
- [InternVL: Scaling up Vision Foundation Models and Aligning for Generic Visual-Linguistic Tasks](https://mlsanity.com/paper/2312.14238/) (2023)
- [MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGI](https://mlsanity.com/paper/2311.16502/) (2023)
- [InternVL3: Exploring Advanced Training and Test-Time Recipes for Open-Source Multimodal Models](https://mlsanity.com/paper/2504.10479/) (2025)
- [Expanding Performance Boundaries of Open-Source Multimodal Models with Model, Data, and Test-Time Scaling](https://mlsanity.com/paper/2412.05271/) (2024)
- [A Survey on LLM-as-a-Judge](https://mlsanity.com/paper/2411.15594/) (2024)
- [How Far Are We to GPT-4V? Closing the Gap to Commercial Multimodal Models with Open-Source Suites](https://mlsanity.com/paper/2404.16821/) (2024)
- [A Diagram Is Worth A Dozen Images](https://mlsanity.com/paper/1603.07396/) (2016)
- [The Dawn of LMMs: Preliminary Explorations with GPT-4V(ision)](https://mlsanity.com/paper/2309.17421/) (2023)
- [MathVerse: Does Your Multi-modal LLM Truly See the Diagrams in Visual Math Problems?](https://mlsanity.com/paper/2403.14624/) (2024)
- [Measuring Multimodal Mathematical Reasoning with MATH-Vision Dataset](https://mlsanity.com/paper/2402.14804/) (2024)
- [Multimodal Chain-of-Thought Reasoning: A Comprehensive Survey](https://mlsanity.com/paper/2503.12605/) (2025)
- [VisualPRM: An Effective Process Reward Model for Multimodal Reasoning](https://mlsanity.com/paper/2503.10291/) (2025)
- [Can MLLMs Reason in Multimodality? EMMA: An Enhanced MultiModal ReAsoning Benchmark](https://mlsanity.com/paper/2501.05444/) (2025)
- [A Survey of Efficient Reasoning for Large Reasoning Models: Language, Multimodality, and Beyond](https://mlsanity.com/paper/2503.21614/) (2025)
- [MME-CoT: Benchmarking Chain-of-Thought in Large Multimodal Models for Reasoning Quality, Robustness, and Efficiency](https://mlsanity.com/paper/2502.09621/) (2025)
- [Let's reward step by step: Step-Level reward model as the Navigators for Reasoning](https://mlsanity.com/paper/2310.10080/) (2023)
- [PRMBench: A Fine-grained and Challenging Benchmark for Process-Level Reward Models](https://mlsanity.com/paper/2501.03124/) (2025)
- [GMAI-MMBench: A Comprehensive Multimodal Evaluation Benchmark Towards General Medical AI](https://mlsanity.com/paper/2408.03361/) (2024)
- [Perception, Reason, Think, and Plan: A Survey on Large Multimodal Reasoning Models](https://mlsanity.com/paper/2505.04921/) (2025)
- [Skywork R1V: Pioneering Multimodal Reasoning with Chain-of-Thought](https://mlsanity.com/paper/2504.05599/) (2025)
- [PhyX: Does Your Model Have the "Wits" for Physical Reasoning?](https://mlsanity.com/paper/2505.15929/) (2025)
- [R-Bench: Graduate-level Multi-disciplinary Benchmarks for LLM & MLLM Complex Reasoning Evaluation](https://mlsanity.com/paper/2505.02018/) (2025)
- [A Survey on Multimodal Benchmarks: In the Era of Large AI Models](https://mlsanity.com/paper/2409.18142/) (2024)
- [GeoSense: Evaluating Identification and Application of Geometric Principles in Multimodal Reasoning](https://mlsanity.com/paper/2504.12597/) (2025)

## Built on by (most cited first, 6 of 6)

- [Aligning Perception, Reasoning, Modeling and Interaction: A Survey on Physical AI](https://mlsanity.com/paper/2510.04978/) (2025)
- [Contrastive On-Policy Distillation](https://mlsanity.com/paper/2607.19046/) (2026)
- [ChemVTS-Bench: Evaluating Visual-Textual-Symbolic Reasoning of Multimodal Large Language Models in Chemistry](https://mlsanity.com/paper/2511.17909/) (2025)
- [Science Edge Evaluation: SEE the Missing Step Toward Real Scientific Discovery](https://mlsanity.com/paper/2608.06931/) (2026)
- [MatPhaseBench: A Semantics-Guided Benchmark for Materials Phase Diagrams Understanding](https://mlsanity.com/paper/2607.02934/) (2026)
- [Trinity: Self-Evolving Vision-Language Models with a Self-Verifier](https://mlsanity.com/paper/2610.04469/) (2026)

## Abstract (arXiv)

Recently, multimodal large language models (MLLMs) have achieved significant advancements across various domains, and corresponding evaluation benchmarks have been continuously refined and improved. In this process, benchmarks in the scientific domain have played an important role in assessing the reasoning capabilities of MLLMs. However, existing benchmarks still face three key challenges: 1) Insufficient evaluation of models' reasoning abilities in multilingual scenarios; 2) Inadequate assessment of MLLMs' comprehensive modality coverage; 3) Lack of fine-grained annotation of scientific knowledge points. To address these gaps, we propose MME-SCI, a comprehensive and challenging benchmark. We carefully collected 1,019 high-quality question-answer pairs, which involve 3 distinct evaluation modes. These pairs cover four subjects, namely mathematics, physics, chemistry, and biology, and support five languages: Chinese, English, French, Spanish, and Japanese. We conducted extensive experiments on 16 open-source models and 4 closed-source models, and the results demonstrate that MME-SCI is widely challenging for existing MLLMs. For instance, under the Image-only evaluation mode, o4-mini achieved accuracy of only 52.11%, 24.73%, 36.57%, and 29.80% in mathematics, physics, chemistry, and biology, respectively, indicating a significantly higher difficulty level compared to existing benchmarks. More importantly, using MME-SCI's multilingual and fine-grained knowledge attributes, we analyzed existing models' performance in depth and identified their weaknesses in specific domains. The Data and Evaluation Code are available at https://github.com/JCruan519/MME-SCI.