# EEG-MedRAG: Enhancing EEG-based Clinical Decision-Making via Hierarchical Hypergraph Retrieval-Augmented Generation

arXiv: https://arxiv.org/abs/2508.13735 · HTML: https://mlsanity.com/paper/2508.13735/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 23 of its 63 references that are in the map.
- First posted on arXiv 19 Aug 2025.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)

## Builds on (most cited first, 23 of 23)

- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Self-RAG: Learning to Retrieve, Generate, and Critique through Self-Reflection](https://mlsanity.com/paper/2310.11511/) (2023)
- [Reasoning on Graphs: Faithful and Interpretable Large Language Model Reasoning](https://mlsanity.com/paper/2310.01061/) (2023)
- [Graph Retrieval-Augmented Generation: A Survey](https://mlsanity.com/paper/2408.08921/) (2024)
- [MedAlpaca -- An Open-Source Collection of Medical Conversational AI Models and Training Data](https://mlsanity.com/paper/2304.08247/) (2023)
- [LinkBERT: Pretraining Language Models with Document Links](https://mlsanity.com/paper/2203.15827/) (2022)
- [Retrieval-Augmented Generation with Graphs (GraphRAG)](https://mlsanity.com/paper/2501.00309/) (2024)
- [Deep learning-based electroencephalography analysis: a systematic review](https://mlsanity.com/paper/1901.05498/) (2019)
- [KG-BART: Knowledge Graph-Augmented BART for Generative Commonsense Reasoning](https://mlsanity.com/paper/2009.12677/) (2020)
- [MedRAG: Enhancing Retrieval-augmented Generation with Knowledge Graph-Elicited Reasoning for Healthcare Copilot](https://mlsanity.com/paper/2502.04413/) (2025)
- [HyperGraphRAG: Retrieval-Augmented Generation via Hypergraph-Structured Knowledge Representation](https://mlsanity.com/paper/2503.21322/) (2025)
- [Knowledge Graph-Augmented Language Models for Knowledge-Grounded Dialogue Generation](https://mlsanity.com/paper/2305.18846/) (2023)
- [LLM-based Medical Assistant Personalization with Short- and Long-Term Memory Coordination](https://mlsanity.com/paper/2309.11696/) (2023)
- [DyKgChat: Benchmarking Dialogue Generation Grounding on Dynamic Knowledge Graphs](https://mlsanity.com/paper/1910.00610/) (2019)
- [TC-RAG:Turing-Complete RAG's Case study on Medical LLM Systems](https://mlsanity.com/paper/2408.09199/) (2024)
- [ReasoningLM: Enabling Structural Subgraph Reasoning in Pre-trained Language Models for Question Answering over Knowledge Graph](https://mlsanity.com/paper/2401.00158/) (2023)
- [Healthcare Copilot: Eliciting the Power of General LLMs for Medical Consultation](https://mlsanity.com/paper/2402.13408/) (2024)
- [Self-Supervised Graph Learning with Hyperbolic Embedding for Temporal Health Event Prediction](https://mlsanity.com/paper/2106.04751/) (2021)
- [Almanac Copilot: Towards Autonomous Electronic Health Record Navigation](https://mlsanity.com/paper/2405.07896/) (2024)
- [TransSleep: Transitioning-aware Attention-based Deep Neural Network for Sleep Staging](https://mlsanity.com/paper/2203.12590/) (2022)
- [DHGE: Dual-View Hyper-Relational Knowledge Graph Embedding for Link Prediction and Entity Typing](https://mlsanity.com/paper/2207.08562/) (2022)
- [An EEG-based approach for Parkinson's disease diagnosis using Capsule network](https://mlsanity.com/paper/2201.00628/) (2021)
- [KGCompiler: Deep Learning Compilation Optimization for Knowledge Graph Complex Logical Query Answering](https://mlsanity.com/paper/2503.02172/) (2025)

## Built on by (most cited first, 1 of 1)

- [Large language models in medical time series analysis](https://mlsanity.com/paper/2609.22262/) (2026)

## Abstract (arXiv)

With the widespread application of electroencephalography (EEG) in neuroscience and clinical practice, efficiently retrieving and semantically interpreting large-scale, multi-source, heterogeneous EEG data has become a pressing challenge. We propose EEG-MedRAG, a three-layer hypergraph-based retrieval-augmented generation framework that unifies EEG domain knowledge, individual patient cases, and a large-scale repository into a traversable n-ary relational hypergraph, enabling joint semantic-temporal retrieval and causal-chain diagnostic generation. Concurrently, we introduce the first cross-disease, cross-role EEG clinical QA benchmark, spanning seven disorders and five authentic clinical perspectives. This benchmark allows systematic evaluation of disease-agnostic generalization and role-aware contextual understanding. Experiments show that EEG-MedRAG significantly outperforms TimeRAG and HyperGraphRAG in answer accuracy and retrieval, highlighting its strong potential for real-world clinical decision support. Our data and code are publicly available at https://github.com/yi9206413-boop/EEG-MedRAG.