# DermINO: Hybrid Pretraining for a Versatile Dermatology Foundation Model

arXiv: https://arxiv.org/abs/2508.12190 · HTML: https://mlsanity.com/paper/2508.12190/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 26 of its 58 references that are in the map.
- First posted on arXiv 17 Aug 2025.

## Builds on (most cited first, 26 of 26)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [SGDR: Stochastic Gradient Descent with Warm Restarts](https://mlsanity.com/paper/1608.03983/) (2016)
- [Sigmoid Loss for Language Image Pre-Training](https://mlsanity.com/paper/2303.15343/) (2023)
- [Unsupervised Learning of Visual Features by Contrasting Cluster Assignments](https://mlsanity.com/paper/2006.09882/) (2020)
- [An Empirical Study of Training Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.02057/) (2021)
- [Unified Perceptual Parsing for Scene Understanding](https://mlsanity.com/paper/1807.10221/) (2018)
- [iBOT: Image BERT Pre-Training with Online Tokenizer](https://mlsanity.com/paper/2111.07832/) (2021)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [How to train your ViT? Data, Augmentation, and Regularization in Vision Transformers](https://mlsanity.com/paper/2106.10270/) (2021)
- [Skin Lesion Analysis Toward Melanoma Detection: A Challenge at the 2017 International Symposium on Biomedical Imaging (ISBI), Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1710.05006/) (2017)
- [Flower: A Friendly Federated Learning Research Framework](https://mlsanity.com/paper/2007.14390/) (2020)
- [Evaluation: from precision, recall and F-measure to ROC, informedness, markedness and correlation](https://mlsanity.com/paper/2010.16061/) (2020)
- [BioMistral: A Collection of Open-Source Pretrained Large Language Models for Medical Domains](https://mlsanity.com/paper/2402.10373/) (2024)
- [Skin Lesion Analysis toward Melanoma Detection: A Challenge at the International Symposium on Biomedical Imaging (ISBI) 2016, hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1605.01397/) (2016)
- [Evaluating Deep Neural Networks Trained on Clinical Images in Dermatology with the Fitzpatrick 17k Dataset](https://mlsanity.com/paper/2104.09957/) (2021)
- [Disparities in Dermatology AI: Assessments Using Diverse Clinical Images](https://mlsanity.com/paper/2111.08006/) (2021)
- [Spreading vectors for similarity search](https://mlsanity.com/paper/1806.03198/) (2018)
- [A deep learning system for differential diagnosis of skin diseases](https://mlsanity.com/paper/1909.05382/) (2019)
- [LVM-Med: Learning Large-Scale Self-Supervised Vision Models for Medical Imaging via Second-order Graph Matching](https://mlsanity.com/paper/2306.11925/) (2023)
- [CODER: Knowledge infused cross-lingual medical term embedding for term normalization](https://mlsanity.com/paper/2011.02947/) (2020)
- [MedImageInsight: An Open-Source Embedding Model for General Domain Medical Imaging](https://mlsanity.com/paper/2410.06542/) (2024)
- [Towards a Holistic Framework for Multimodal Large Language Models in Three-dimensional Brain CT Report Generation](https://mlsanity.com/paper/2407.02235/) (2024)
- [The impact of patient clinical information on automated skin cancer detection](https://mlsanity.com/paper/1909.12912/) (2019)
- [Crowdsourcing Dermatology Images with Google Search Ads: Creating a Real-World Skin Condition Dataset](https://mlsanity.com/paper/2402.18545/) (2024)

## Built on by (most cited first, 2 of 2)

- [Towards Trustworthy Dermatology MLLMs: A Benchmark and Multimodal Evaluator for Diagnostic Narratives](https://mlsanity.com/paper/2511.09195/) (2025)
- [Dual-Branch Cross-Projection Debiasing through Diffusion-based Disentanglement](https://mlsanity.com/paper/2606.24161/) (2026)

## Abstract (arXiv)

Skin diseases impose a substantial burden on global healthcare systems, driven by their high prevalence (affecting up to 70% of the population), complex diagnostic processes, and a critical shortage of dermatologists in resource-limited areas. While artificial intelligence(AI) tools have demonstrated promise in dermatological image analysis, current models face limitations-they often rely on large, manually labeled datasets and are built for narrow, specific tasks, making them less effective in real-world settings. To tackle these limitations, we present DermNIO, a versatile foundation model for dermatology. Trained on a curated dataset of 432,776 images from three sources (public repositories, web-sourced images, and proprietary collections), DermNIO incorporates a novel hybrid pretraining framework that augments the self-supervised learning paradigm through semi-supervised learning and knowledge-guided prototype initialization. This integrated method not only deepens the understanding of complex dermatological conditions, but also substantially enhances the generalization capability across various clinical tasks. Evaluated across 20 datasets, DermNIO consistently outperforms state-of-the-art models across a wide range of tasks. It excels in high-level clinical applications including malignancy classification, disease severity grading, multi-category diagnosis, and dermatological image caption, while also achieving state-of-the-art performance in low-level tasks such as skin lesion segmentation. Furthermore, DermNIO demonstrates strong robustness in privacy-preserving federated learning scenarios and across diverse skin types and sexes. In a blinded reader study with 23 dermatologists, DermNIO achieved 95.79% diagnostic accuracy (versus clinicians' 73.66%), and AI assistance improved clinician performance by 17.21%.