# QuarkMed Medical Foundation Model Technical Report

arXiv: https://arxiv.org/abs/2508.11894 · HTML: https://mlsanity.com/paper/2508.11894/

## Key facts

- Cited by 5 papers in the map (data through 14 Oct 2026).
- Builds on 35 of its 46 references that are in the map.
- First posted on arXiv 16 Aug 2025.

## Builds on (most cited first, 30 of 35)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learning](https://mlsanity.com/paper/2501.12948/) (2025)
- [Training a Helpful and Harmless Assistant with Reinforcement Learning from Human Feedback](https://mlsanity.com/paper/2204.05862/) (2022)
- [Self-Instruct: Aligning Language Models with Self-Generated Instructions](https://mlsanity.com/paper/2212.10560/) (2022)
- [HybridFlow: A Flexible and Efficient RLHF Framework](https://mlsanity.com/paper/2409.19256/) (2024)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Multitask Prompted Training Enables Zero-Shot Task Generalization](https://mlsanity.com/paper/2110.08207/) (2021)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Scaling Laws for Reward Model Overoptimization](https://mlsanity.com/paper/2210.10760/) (2022)
- [Super-NaturalInstructions: Generalization via Declarative Instructions on 1600+ NLP Tasks](https://mlsanity.com/paper/2204.07705/) (2022)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [BioGPT: Generative Pre-trained Transformer for Biomedical Text Generation and Mining](https://mlsanity.com/paper/2210.10341/) (2022)
- [ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmission](https://mlsanity.com/paper/1904.05342/) (2019)
- [Towards Expert-Level Medical Question Answering with Large Language Models](https://mlsanity.com/paper/2305.09617/) (2023)
- [MEDITRON-70B: Scaling Medical Pretraining for Large Language Models](https://mlsanity.com/paper/2311.16079/) (2023)
- [BEHRT: Transformer for Electronic Health Records](https://mlsanity.com/paper/1907.09538/) (2019)
- [MedXpertQA: Benchmarking Expert-Level Medical Reasoning and Understanding](https://mlsanity.com/paper/2501.18362/) (2025)
- [Crossing the Reward Bridge: Expanding RL with Verifiable Rewards Across Diverse Domains](https://mlsanity.com/paper/2503.23829/) (2025)
- [MediQ: Question-Asking LLMs and a Benchmark for Reliable Interactive Clinical Reasoning](https://mlsanity.com/paper/2406.00922/) (2024)
- [Benchmarking Large Language Models on Answering and Explaining Challenging Medical Questions](https://mlsanity.com/paper/2402.18060/) (2024)
- [Benchmarking Large Language Models on CMExam -- A Comprehensive Chinese Medical Exam Dataset](https://mlsanity.com/paper/2306.03030/) (2023)
- [PMC-LLaMA: Towards Building Open-source Language Models for Medicine](https://mlsanity.com/paper/2304.14454/) (2023)
- [MedCalc-Bench: Evaluating Large Language Models for Medical Calculations](https://mlsanity.com/paper/2406.12036/) (2024)

## Built on by (most cited first, 5 of 5)

- [ATPO: Adaptive Tree Policy Optimization for Multi-Turn Medical Dialogue](https://mlsanity.com/paper/2603.02216/) (2026)
- [MedXIAOHE: A Comprehensive Recipe for Building Medical MLLMs](https://mlsanity.com/paper/2602.12705/) (2026)
- [Medical Reasoning with Large Language Models: A Survey and MR-Bench](https://mlsanity.com/paper/2604.08559/) (2026)
- [Quark Medical Alignment: A Holistic Multi-Dimensional Alignment and Collaborative Optimization Paradigm](https://mlsanity.com/paper/2602.11661/) (2026)
- [QuarkMedBench: A Real-World Scenario Driven Benchmark for Evaluating Large Language Models](https://mlsanity.com/paper/2603.13691/) (2026)

## Abstract (arXiv)

Recent advancements in large language models have significantly accelerated their adoption in healthcare applications, including AI-powered medical consultations, diagnostic report assistance, and medical search tools. However, medical tasks often demand highly specialized knowledge, professional accuracy, and customization capabilities, necessitating a robust and reliable foundation model. QuarkMed addresses these needs by leveraging curated medical data processing, medical-content Retrieval-Augmented Generation (RAG), and a large-scale, verifiable reinforcement learning pipeline to develop a high-performance medical foundation model. The model achieved 70% accuracy on the Chinese Medical Licensing Examination, demonstrating strong generalization across diverse medical benchmarks. QuarkMed offers a powerful yet versatile personal medical AI solution, already serving over millions of users at ai.quark.cn.