# Contrastive Regularization over LoRA for Multimodal Biomedical Image Incremental Learning

arXiv: https://arxiv.org/abs/2508.11673 · HTML: https://mlsanity.com/paper/2508.11673/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 34 of its 53 references that are in the map.
- First posted on arXiv 8 Aug 2025.

## Builds on (most cited first, 30 of 34)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Parameter-Efficient Transfer Learning for NLP](https://mlsanity.com/paper/1902.00751/) (2019)
- [The Power of Scale for Parameter-Efficient Prompt Tuning](https://mlsanity.com/paper/2104.08691/) (2021)
- [iCaRL: Incremental Classifier and Representation Learning](https://mlsanity.com/paper/1611.07725/) (2016)
- [Learning to Prompt for Vision-Language Models](https://mlsanity.com/paper/2109.01134/) (2021)
- [Gradient Episodic Memory for Continual Learning](https://mlsanity.com/paper/1706.08840/) (2017)
- [Continual Lifelong Learning with Neural Networks: A Review](https://mlsanity.com/paper/1802.07569/) (2018)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [Memory Aware Synapses: Learning what (not) to forget](https://mlsanity.com/paper/1711.09601/) (2017)
- [CLIP-Adapter: Better Vision-Language Models with Feature Adapters](https://mlsanity.com/paper/2110.04544/) (2021)
- [PackNet: Adding Multiple Tasks to a Single Network by Iterative Pruning](https://mlsanity.com/paper/1711.05769/) (2017)
- [Mixture-of-Experts with Expert Choice Routing](https://mlsanity.com/paper/2202.09368/) (2022)
- [PathVQA: 30000+ Questions for Medical Visual Question Answering](https://mlsanity.com/paper/2003.10286/) (2020)
- [SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answering](https://mlsanity.com/paper/2102.09542/) (2021)
- [Rotation Equivariant CNNs for Digital Pathology](https://mlsanity.com/paper/1806.03962/) (2018)
- [Expert Gate: Lifelong Learning with a Network of Experts](https://mlsanity.com/paper/1611.06194/) (2016)
- [Gradient Projection Memory for Continual Learning](https://mlsanity.com/paper/2103.09762/) (2021)
- [VL-Adapter: Parameter-Efficient Transfer Learning for Vision-and-Language Tasks](https://mlsanity.com/paper/2112.06825/) (2021)
- [DyTox: Transformers for Continual Learning with DYnamic TOken eXpansion](https://mlsanity.com/paper/2111.11326/) (2021)
- [Selective Experience Replay for Lifelong Learning](https://mlsanity.com/paper/1802.10269/) (2018)
- [BiomedGPT: A Generalist Vision-Language Foundation Model for Diverse Biomedical Tasks](https://mlsanity.com/paper/2305.17100/) (2023)
- [InfLoRA: Interference-Free Low-Rank Adaptation for Continual Learning](https://mlsanity.com/paper/2404.00228/) (2024)
- [Boosting Continual Learning of Vision-Language Models via Mixture-of-Experts Adapters](https://mlsanity.com/paper/2403.11549/) (2024)
- [Evaluating Deep Neural Networks Trained on Clinical Images in Dermatology with the Fitzpatrick 17k Dataset](https://mlsanity.com/paper/2104.09957/) (2021)
- [Quilt-LLaVA: Visual Instruction Tuning by Extracting Localized Narratives from Open-Source Histopathology Videos](https://mlsanity.com/paper/2312.04746/) (2023)
- [SD-LoRA: Scalable Decoupled Low-Rank Adaptation for Class Incremental Learning](https://mlsanity.com/paper/2501.13198/) (2025)
- [A Survey on Biomedical Image Captioning](https://mlsanity.com/paper/1905.13302/) (2019)
- [VL-PET: Vision-and-Language Parameter-Efficient Tuning via Granularity Control](https://mlsanity.com/paper/2308.09804/) (2023)

## Built on by (most cited first, 2 of 2)

- [Forging a Dynamic Memory: Retrieval-Guided Continual Learning for Generalist Medical Foundation Models](https://mlsanity.com/paper/2512.13072/) (2025)
- [MOSAIC: Modality-Specific Adaptation for Incremental Continual Learning in Parkinson's Disease Gait Assessment](https://mlsanity.com/paper/2606.13258/) (2026)

## Abstract (arXiv)

Multimodal Biomedical Image Incremental Learning (MBIIL) is essential for handling diverse tasks and modalities in the biomedical domain, as training separate models for each modality or task significantly increases inference costs. Existing incremental learning methods focus on task expansion within a single modality, whereas MBIIL seeks to train a unified model incrementally across modalities. The MBIIL faces two challenges: I) How to preserve previously learned knowledge during incremental updates? II) How to effectively leverage knowledge acquired from existing modalities to support new modalities? To address these challenges, we propose MSLoRA-CR, a method that fine-tunes Modality-Specific LoRA modules while incorporating Contrastive Regularization to enhance intra-modality knowledge sharing and promote inter-modality knowledge differentiation. Our approach builds upon a large vision-language model (LVLM), keeping the pretrained model frozen while incrementally adapting new LoRA modules for each modality or task. Experiments on the incremental learning of biomedical images demonstrate that MSLoRA-CR outperforms both the state-of-the-art (SOTA) approach of training separate models for each modality and the general incremental learning method (incrementally fine-tuning LoRA). Specifically, MSLoRA-CR achieves a 1.88% improvement in overall performance compared to unconstrained incremental learning methods while maintaining computational efficiency. Our code is publicly available at https://github.com/VentusAislant/MSLoRA_CR.