# AnatoMaskGAN: GNN-Driven Slice Feature Fusion and Noise Augmentation for Medical Semantic Image Synthesis

arXiv: https://arxiv.org/abs/2508.11375 · HTML: https://mlsanity.com/paper/2508.11375/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 22 references that are in the map.
- First posted on arXiv 15 Aug 2025.

## Builds on (most cited first, 15 of 15)

- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Conditional Generative Adversarial Nets](https://mlsanity.com/paper/1411.1784/) (2014)
- [Semantic Image Synthesis with Spatially-Adaptive Normalization](https://mlsanity.com/paper/1903.07291/) (2019)
- [A review of deep learning in medical imaging: Imaging traits, technology trends, case studies with progress highlights, and future promises](https://mlsanity.com/paper/2008.09104/) (2020)
- [MedGAN: Medical Image Translation using GANs](https://mlsanity.com/paper/1806.06397/) (2018)
- [Medical Image Synthesis for Data Augmentation and Anonymization using Generative Adversarial Networks](https://mlsanity.com/paper/1807.10225/) (2018)
- [You Only Need Adversarial Supervision for Semantic Image Synthesis](https://mlsanity.com/paper/2012.04781/) (2020)
- [Anatomically-Controllable Medical Image Generation with Segmentation-Guided Diffusion Models](https://mlsanity.com/paper/2402.05210/) (2024)
- [Image Synthesis via Semantic Composition](https://mlsanity.com/paper/2109.07053/) (2021)
- [Dual Attention GANs for Semantic Image Synthesis](https://mlsanity.com/paper/2008.13024/) (2020)
- [Overcoming Barriers to Data Sharing with Medical Image Generation: A Comprehensive Evaluation](https://mlsanity.com/paper/2012.03769/) (2020)
- [COVID-19 CT Image Synthesis with a Conditional Generative Adversarial Network](https://mlsanity.com/paper/2007.14638/) (2020)
- [Semantic-shape Adaptive Feature Modulation for Semantic Image Synthesis](https://mlsanity.com/paper/2203.16898/) (2022)
- [Semantic Image Synthesis for Abdominal CT](https://mlsanity.com/paper/2312.06453/) (2023)

## Abstract (arXiv)

Medical semantic-mask synthesis boosts data augmentation and analysis, yet most GAN-based approaches still produce one-to-one images and lack spatial consistency in complex scans. To address this, we propose AnatoMaskGAN, a novel synthesis framework that embeds slice-related spatial features to precisely aggregate inter-slice contextual dependencies, introduces diverse image-augmentation strategies, and optimizes deep feature learning to improve performance on complex medical images. Specifically, we design a GNN-based strongly correlated slice-feature fusion module to model spatial relationships between slices and integrate contextual information from neighboring slices, thereby capturing anatomical details more comprehensively; we introduce a three-dimensional spatial noise-injection strategy that weights and fuses spatial features with noise to enhance modeling of structural diversity; and we incorporate a grayscale-texture classifier to optimize grayscale distribution and texture representation during generation. Extensive experiments on the public L2R-OASIS and L2R-Abdomen CT datasets show that AnatoMaskGAN raises PSNR on L2R-OASIS to 26.50 dB (0.43 dB higher than the current state of the art) and achieves an SSIM of 0.8602 on L2R-Abdomen CT--a 0.48 percentage-point gain over the best model, demonstrating its superiority in reconstruction accuracy and perceptual quality. Ablation studies that successively remove the slice-feature fusion module, spatial 3D noise-injection strategy, and grayscale-texture classifier reveal that each component contributes significantly to PSNR, SSIM, and LPIPS, further confirming the independent value of each core design in enhancing reconstruction accuracy and perceptual quality.