# Physics-Informed Joint Multi-TE Super-Resolution with Implicit Neural Representation for Robust Fetal T2 Mapping

arXiv: https://arxiv.org/abs/2508.10680 · HTML: https://mlsanity.com/paper/2508.10680/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 9 of its 37 references that are in the map.
- First posted on arXiv 14 Aug 2025.

## Builds on (most cited first, 9 of 9)

- [Implicit Neural Representations with Periodic Activation Functions](https://mlsanity.com/paper/2006.09661/) (2020)
- [SynthSeg: Segmentation of brain MRI scans of any contrast and resolution without retraining](https://mlsanity.com/paper/2107.09559/) (2021)
- [Automated brain extraction of multi-sequence MRI using artificial neural networks](https://mlsanity.com/paper/1901.11341/) (2019)
- [IREM: High-Resolution Magnetic Resonance (MR) Image Reconstruction via Implicit Neural Representation](https://mlsanity.com/paper/2106.15097/) (2021)
- [Single-subject Multi-contrast MRI Super-resolution via Implicit Neural Representations](https://mlsanity.com/paper/2303.15065/) (2023)
- [SVoRT: Iterative Transformer for Slice-to-Volume Registration in Fetal Brain MRI](https://mlsanity.com/paper/2206.10802/) (2022)
- [Meta-learning Slice-to-Volume Reconstruction in Fetal Brain MRI using Implicit Neural Representations](https://mlsanity.com/paper/2505.09565/) (2025)
- [T2 Mapping from Super-Resolution-Reconstructed Clinical Fast Spin Echo Magnetic Resonance Acquisitions](https://mlsanity.com/paper/2007.12199/) (2020)
- [Evaluating Synthetic Data Generation for Domain Generalization in Fetal Brain MRI Segmentation](https://mlsanity.com/paper/2411.06842/) (2024)

## Built on by (most cited first, 1 of 1)

- [PRIME-SVR: Physics-infoRmed Implicit Multi-Echo Slice-to-Volume Reconstruction for Fetal T2 mapping](https://mlsanity.com/paper/2607.20136/) (2026)

## Abstract (arXiv)

T2 mapping in fetal brain MRI has the potential to improve characterization of the developing brain, especially at mid-field (0.55T), where T2 decay is slower. However, this is challenging as fetal MRI acquisition relies on multiple motion-corrupted stacks of thick slices, requiring slice-to-volume reconstruction (SVR) to estimate a high-resolution (HR) 3D volume. Currently, T2 mapping involves repeated acquisitions of these stacks at each echo time (TE), leading to long scan times and high sensitivity to motion. We tackle this challenge with a method that jointly reconstructs data across TEs, addressing severe motion. Our approach combines implicit neural representations with a physics-informed regularization that models T2 decay, enabling information sharing across TEs while preserving anatomical and quantitative T2 fidelity. We demonstrate state-of-the-art performance on simulated fetal brain and in vivo adult datasets with fetal-like motion. We also present the first in vivo fetal T2 mapping results at 0.55T. Our study shows potential for reducing the number of stacks per TE in T2 mapping by leveraging anatomical redundancy.