# A Generative Imputation Method for Multimodal Alzheimer's Disease Diagnosis

arXiv: https://arxiv.org/abs/2508.09271 · HTML: https://mlsanity.com/paper/2508.09271/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 5 of its 20 references that are in the map.
- First posted on arXiv 12 Aug 2025.

## Builds on (most cited first, 5 of 5)

- [Generative Adversarial Networks](https://mlsanity.com/paper/2203.00667/) (2022)
- [Image Synthesis in Multi-Contrast MRI with Conditional Generative Adversarial Networks](https://mlsanity.com/paper/1802.01221/) (2018)
- [A Domain Translation Framework with an Adversarial Denoising Diffusion Model to Generate Synthetic Datasets of Echocardiography Images](https://mlsanity.com/paper/2403.04612/) (2024)
- [Evaluation of 3D GANs for Lung Tissue Modelling in Pulmonary CT](https://mlsanity.com/paper/2208.08184/) (2022)
- [Cross-Modality Translation with Generative Adversarial Networks to Unveil Alzheimer's Disease Biomarkers](https://mlsanity.com/paper/2405.05462/) (2024)

## Built on by (most cited first, 1 of 1)

- [An Interdisciplinary and Cross-Task Review on Missing Data Imputation](https://mlsanity.com/paper/2511.01196/) (2025)

## Abstract (arXiv)

Multimodal data analysis can lead to more accurate diagnoses of brain disorders due to the complementary information that each modality adds. However, a major challenge of using multimodal datasets in the neuroimaging field is incomplete data, where some of the modalities are missing for certain subjects. Hence, effective strategies are needed for completing the data. Traditional methods, such as subsampling or zero-filling, may reduce the accuracy of predictions or introduce unintended biases. In contrast, advanced methods such as generative models have emerged as promising solutions without these limitations. In this study, we proposed a generative adversarial network method designed to reconstruct missing modalities from existing ones while preserving the disease patterns. We used T1-weighted structural magnetic resonance imaging and functional network connectivity as two modalities. Our findings showed a 9% improvement in the classification accuracy for Alzheimer's disease versus cognitive normal groups when using our generative imputation method compared to the traditional approaches.