# Zero-shot self-supervised learning of single breath-hold magnetic resonance cholangiopancreatography (MRCP) reconstruction

arXiv: https://arxiv.org/abs/2508.09200 · HTML: https://mlsanity.com/paper/2508.09200/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 10 of its 51 references that are in the map.
- First posted on arXiv 8 Aug 2025.

## Builds on (most cited first, 10 of 10)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [SGDR: Stochastic Gradient Descent with Warm Restarts](https://mlsanity.com/paper/1608.03983/) (2016)
- [Implicit Neural Representations with Periodic Activation Functions](https://mlsanity.com/paper/2006.09661/) (2020)
- [Deep Image Prior](https://mlsanity.com/paper/1711.10925/) (2017)
- [MoDL: Model Based Deep Learning Architecture for Inverse Problems](https://mlsanity.com/paper/1712.02862/) (2017)
- [Zero-Shot Self-Supervised Learning for MRI Reconstruction](https://mlsanity.com/paper/2102.07737/) (2021)
- [IMJENSE: Scan-specific Implicit Representation for Joint Coil Sensitivity and Image Estimation in Parallel MRI](https://mlsanity.com/paper/2311.12892/) (2023)
- [Improved Multi-Shot Diffusion-Weighted MRI with Zero-Shot Self-Supervised Learning Reconstruction](https://mlsanity.com/paper/2308.05103/) (2023)
- [Robust partial Fourier reconstruction for diffusion-weighted imaging using a recurrent convolutional neural network](https://mlsanity.com/paper/2105.09378/) (2021)
- [Deep Learning-based Accelerated MR Cholangiopancreatography without Fully-sampled Data](https://mlsanity.com/paper/2405.03732/) (2024)

## Abstract (arXiv)

To investigate the feasibility of zero-shot self-supervised learning reconstruction for reducing breath-hold times in magnetic resonance cholangiopancreatography (MRCP). Breath-hold MRCP was acquired from 11 healthy volunteers on 3T scanners using an incoherent k-space sampling pattern, leading to 14-second acquisition time and an acceleration factor of R=25. Zero-shot reconstruction was compared with parallel imaging of respiratory-triggered MRCP (338s, R=3) and compressed sensing reconstruction. For two volunteers, breath-hold scans (40s, R=6) were additionally acquired and retrospectively undersampled to R=25 to compute peak signal-to-noise ratio (PSNR). To address long zero-shot training time, the n+m full stages of the zero-shot learning were divided into two parts to reduce backpropagation depth during training: 1) n frozen stages initialized with n-stage pretrained network and 2) m trainable stages initialized either randomly or m-stage pretrained network. Efficiency of our approach was assessed by varying initialization strategies and the number of trainable stages using the retrospectively undersampled data. Zero-shot reconstruction significantly improved visual image quality over compressed sensing, particularly in SNR and ductal delineation, and achieved image quality comparable to that of successful respiratory-triggered acquisitions with regular breathing patterns. Improved initializations enhanced PSNR and reduced reconstruction time. Adjusting frozen/trainable configurations demonstrated that PSNR decreased only slightly from 38.25 dB (0/13) to 37.67 dB (12/1), while training time decreased up to 6.7-fold. Zero-shot learning delivers high-fidelity MRCP reconstructions with reduced breath-hold times, and the proposed partially trainable approach offers a practical solution for translation into time-constrained clinical workflows.