# DepressLLM: Interpretable domain-adapted language model for depression detection from real-world narratives

arXiv: https://arxiv.org/abs/2508.08591 · HTML: https://mlsanity.com/paper/2508.08591/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 15 of its 39 references that are in the map.
- First posted on arXiv 12 Aug 2025.

## Builds on (most cited first, 15 of 15)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Qwen3 Technical Report](https://mlsanity.com/paper/2505.09388/) (2025)
- [XGBoost: A Scalable Tree Boosting System](https://mlsanity.com/paper/1603.02754/) (2016)
- [Neural Machine Translation by Jointly Learning to Align and Translate](https://mlsanity.com/paper/1409.0473/) (2014)
- [Simple and Scalable Predictive Uncertainty Estimation using Deep Ensembles](https://mlsanity.com/paper/1612.01474/) (2016)
- [Competition-Level Code Generation with AlphaCode](https://mlsanity.com/paper/2203.07814/) (2022)
- [Phi-4 Technical Report](https://mlsanity.com/paper/2412.08905/) (2024)
- [MentalBERT: Publicly Available Pretrained Language Models for Mental Healthcare](https://mlsanity.com/paper/2110.15621/) (2021)
- [MentaLLaMA: Interpretable Mental Health Analysis on Social Media with Large Language Models](https://mlsanity.com/paper/2309.13567/) (2023)
- [Decoding Linguistic Nuances in Mental Health Text Classification Using Expressive Narrative Stories](https://mlsanity.com/paper/2412.16302/) (2024)

## Built on by (most cited first, 3 of 3)

- [LENS: LLM-Enabled Narrative Synthesis for Mental Health by Aligning Multimodal Sensing with Language Models](https://mlsanity.com/paper/2512.23025/) (2025)
- [Dep-LLM: Training-Free Depression Diagnosis via Evidence-Guided Structured Multi-factor with Reliable LLM Reasoning](https://mlsanity.com/paper/2606.10796/) (2026)
- [From Pattern Recognizers to Personalized Companions: A Survey of Large Language Models in Mental Health](https://mlsanity.com/paper/2609.25186/) (2026)

## Abstract (arXiv)

Advances in large language models (LLMs) have enabled a wide range of applications. However, depression prediction is hindered by the lack of large-scale, high-quality, and rigorously annotated datasets. This study introduces DepressLLM, trained and evaluated on a novel corpus of 3,699 autobiographical narratives reflecting both happiness and distress. DepressLLM provides interpretable depression predictions and, via its Score-guided Token Probability Summation (SToPS) module, delivers both improved classification performance and reliable confidence estimates, achieving an AUC of 0.789, which rises to 0.904 on samples with confidence ≥ 0.95. To validate its robustness to heterogeneous data, we evaluated DepressLLM on in-house datasets, including an Ecological Momentary Assessment (EMA) corpus of daily stress and mood recordings, and on public clinical interview data. Finally, a psychiatric review of high-confidence misclassifications highlighted key model and data limitations that suggest directions for future refinements. These findings demonstrate that interpretable AI can enable earlier diagnosis of depression and underscore the promise of medical AI in psychiatry.