# NeuroDx-LM: A Clinical Large-Scale Model for EEG-based Neurological Disorder Detection

arXiv: https://arxiv.org/abs/2508.08124 · HTML: https://mlsanity.com/paper/2508.08124/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 24 references that are in the map.
- First posted on arXiv 11 Aug 2025.

## Builds on (most cited first, 9 of 9)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Gaussian Error Linear Units (GELUs)](https://mlsanity.com/paper/1606.08415/) (2016)
- [Group Normalization](https://mlsanity.com/paper/1803.08494/) (2018)
- [Large Brain Model for Learning Generic Representations with Tremendous EEG Data in BCI](https://mlsanity.com/paper/2405.18765/) (2024)
- [Transformer-based Spatial-Temporal Feature Learning for EEG Decoding](https://mlsanity.com/paper/2106.11170/) (2021)
- [Transformer Convolutional Neural Networks for Automated Artifact Detection in Scalp EEG](https://mlsanity.com/paper/2208.02405/) (2022)
- [Let's Learn Step by Step: Enhancing In-Context Learning Ability with Curriculum Learning](https://mlsanity.com/paper/2402.10738/) (2024)
- [A Survey on Medical Large Language Models: Technology, Application, Trustworthiness, and Future Directions](https://mlsanity.com/paper/2406.03712/) (2024)
- [An Automated System for Epilepsy Detection using EEG Brain Signals based on Deep Learning Approach](https://mlsanity.com/paper/1801.05412/) (2018)

## Abstract (arXiv)

Large-scale models pre-trained on Electroencephalography (EEG) have shown promise in clinical applications such as neurological disorder detection. However, the practical deployment of EEG-based large-scale models faces critical challenges such as limited labeled EEG data and suboptimal performance in clinical scenarios. To address these issues, we propose NeuroDx-LM, a novel large-scale model specifically designed for detecting EEG-based neurological disorders. Our key contributions include (i) a Selective Temporal-Frequency Embedding mechanism that adaptively captures complex temporal and spectral patterns in EEG signals; and (ii) a Progressive Feature-Aware Training strategy that refines feature representation in a two-stage process. In the first stage, our model learns the fundamental discriminative features of EEG activities; in the second stage, the model further extracts more specialized fine-grained features for accurate diagnostic performance. We evaluated NeuroDx-LM on the CHB-MIT and Schizophrenia datasets, achieving state-of-the-art performance in EEG-based seizure and schizophrenia detection, respectively. These results demonstrate the great potential of EEG-based large-scale models to advance clinical applicability. Our code is available at https://github.com/LetItBe12345/NeuroDx-LM.