# Effortless Vision-Language Model Specialization in Histopathology without Annotation

arXiv: https://arxiv.org/abs/2508.07835 · HTML: https://mlsanity.com/paper/2508.07835/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical vision-language models, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 18 of its 21 references that are in the map.
- First posted on arXiv 11 Aug 2025.

## Placed in

- Multimodal LLMs / vision-language models / [Medical vision-language models](https://mlsanity.com/mllm/medical-vision-language-models/)

## Builds on (most cited first, 18 of 18)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [RoBERTa: A Robustly Optimized BERT Pretraining Approach](https://mlsanity.com/paper/1907.11692/) (2019)
- [LAION-5B: An open large-scale dataset for training next generation image-text models](https://mlsanity.com/paper/2210.08402/) (2022)
- [Learning to Prompt for Vision-Language Models](https://mlsanity.com/paper/2109.01134/) (2021)
- [Gemma 3 Technical Report](https://mlsanity.com/paper/2503.19786/) (2025)
- [Don't Stop Pretraining: Adapt Language Models to Domains and Tasks](https://mlsanity.com/paper/2004.10964/) (2020)
- [Conditional Prompt Learning for Vision-Language Models](https://mlsanity.com/paper/2203.05557/) (2022)
- [CoCa: Contrastive Captioners are Image-Text Foundation Models](https://mlsanity.com/paper/2205.01917/) (2022)
- [CLIP-Adapter: Better Vision-Language Models with Feature Adapters](https://mlsanity.com/paper/2110.04544/) (2021)
- [Tip-Adapter: Training-free Adaption of CLIP for Few-shot Classification](https://mlsanity.com/paper/2207.09519/) (2022)
- [Quilt-1M: One Million Image-Text Pairs for Histopathology](https://mlsanity.com/paper/2306.11207/) (2023)
- [BACH: Grand Challenge on Breast Cancer Histology Images](https://mlsanity.com/paper/1808.04277/) (2018)
- [SuS-X: Training-Free Name-Only Transfer of Vision-Language Models](https://mlsanity.com/paper/2211.16198/) (2022)
- [Low-Rank Few-Shot Adaptation of Vision-Language Models](https://mlsanity.com/paper/2405.18541/) (2024)
- [Going Deeper through the Gleason Scoring Scale: An Automatic end-to-end System for Histology Prostate Grading and Cribriform Pattern Detection](https://mlsanity.com/paper/2105.10490/) (2021)
- [A Petri Dish for Histopathology Image Analysis](https://mlsanity.com/paper/2101.12355/) (2021)
- [PathologyBERT -- Pre-trained Vs. A New Transformer Language Model for Pathology Domain](https://mlsanity.com/paper/2205.06885/) (2022)
- [Model-based Cleaning of the QUILT-1M Pathology Dataset for Text-Conditional Image Synthesis](https://mlsanity.com/paper/2404.07676/) (2024)

## Abstract (arXiv)

Recent advances in Vision-Language Models (VLMs) in histopathology, such as CONCH and QuiltNet, have demonstrated impressive zero-shot classification capabilities across various tasks. However, their general-purpose design may lead to suboptimal performance in specific downstream applications. While supervised fine-tuning methods address this issue, they require manually labeled samples for adaptation. This paper investigates annotation-free adaptation of VLMs through continued pretraining on domain- and task-relevant image-caption pairs extracted from existing databases. Our experiments on two VLMs, CONCH and QuiltNet, across three downstream tasks reveal that these pairs substantially enhance both zero-shot and few-shot performance. Notably, with larger training sizes, continued pretraining matches the performance of few-shot methods while eliminating manual labeling. Its effectiveness, task-agnostic design, and annotation-free workflow make it a promising pathway for adapting VLMs to new histopathology tasks. Code is available at https://github.com/DeepMicroscopy/Annotation-free-VLM-specialization.