# Anatomy-Aware Low-Dose CT Denoising via Pretrained Vision Models and Semantic-Guided Contrastive Learning

arXiv: https://arxiv.org/abs/2508.07788 · HTML: https://mlsanity.com/paper/2508.07788/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 19 of its 33 references that are in the map.
- First posted on arXiv 11 Aug 2025.

## Builds on (most cited first, 19 of 19)

- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [TotalSegmentator: robust segmentation of 104 anatomical structures in CT images](https://mlsanity.com/paper/2208.05868/) (2022)
- [Low-Dose CT with a Residual Encoder-Decoder Convolutional Neural Network (RED-CNN)](https://mlsanity.com/paper/1702.00288/) (2017)
- [CoSeR: Bridging Image and Language for Cognitive Super-Resolution](https://mlsanity.com/paper/2311.16512/) (2023)
- [CoreDiff: Contextual Error-Modulated Generalized Diffusion Model for Low-Dose CT Denoising and Generalization](https://mlsanity.com/paper/2304.01814/) (2023)
- [DU-GAN: Generative Adversarial Networks with Dual-Domain U-Net Based Discriminators for Low-Dose CT Denoising](https://mlsanity.com/paper/2108.10772/) (2021)
- [CTformer: Convolution-free Token2Token Dilated Vision Transformer for Low-dose CT Denoising](https://mlsanity.com/paper/2202.13517/) (2022)
- [SeD: Semantic-Aware Discriminator for Image Super-Resolution](https://mlsanity.com/paper/2402.19387/) (2024)
- [ASCON: Anatomy-aware Supervised Contrastive Learning Framework for Low-dose CT Denoising](https://mlsanity.com/paper/2307.12225/) (2023)
- [Medical Slice Transformer: Improved Diagnosis and Explainability on 3D Medical Images with DINOv2](https://mlsanity.com/paper/2411.15802/) (2024)
- [Task-Oriented Low-Dose CT Image Denoising](https://mlsanity.com/paper/2103.13557/) (2021)
- [DINOv2 based Self Supervised Learning For Few Shot Medical Image Segmentation](https://mlsanity.com/paper/2403.03273/) (2024)
- [Low-dose CT Denoising with Language-engaged Dual-space Alignment](https://mlsanity.com/paper/2403.06128/) (2024)
- [Disease-informed Adaptation of Vision-Language Models](https://mlsanity.com/paper/2405.15728/) (2024)
- [LIDIA: Precise Liver Tumor Diagnosis on Multi-Phase Contrast-Enhanced CT via Iterative Fusion and Asymmetric Contrastive Learning](https://mlsanity.com/paper/2407.13217/) (2024)

## Built on by (most cited first, 2 of 2)

- [FAPE-IR: Frequency-Aware Planning and Execution Framework for All-in-One Image Restoration](https://mlsanity.com/paper/2511.14099/) (2025)
- [Projection Guided Personalized Federated Learning for Low Dose CT Denoising](https://mlsanity.com/paper/2603.13422/) (2026)

## Abstract (arXiv)

To reduce radiation exposure and improve the diagnostic efficacy of low-dose computed tomography (LDCT), numerous deep learning-based denoising methods have been developed to mitigate noise and artifacts. However, most of these approaches ignore the anatomical semantics of human tissues, which may potentially result in suboptimal denoising outcomes. To address this problem, we propose ALDEN, an anatomy-aware LDCT denoising method that integrates semantic features of pretrained vision models (PVMs) with adversarial and contrastive learning. Specifically, we introduce an anatomy-aware discriminator that dynamically fuses hierarchical semantic features from reference normal-dose CT (NDCT) via cross-attention mechanisms, enabling tissue-specific realism evaluation in the discriminator. In addition, we propose a semantic-guided contrastive learning module that enforces anatomical consistency by contrasting PVM-derived features from LDCT, denoised CT and NDCT, preserving tissue-specific patterns through positive pairs and suppressing artifacts via dual negative pairs. Extensive experiments conducted on two LDCT denoising datasets reveal that ALDEN achieves the state-of-the-art performance, offering superior anatomy preservation and substantially reducing over-smoothing issue of previous work. Further validation on a downstream multi-organ segmentation task (encompassing 117 anatomical structures) affirms the model's ability to maintain anatomical awareness.