# Domain Generalization of Pathological Image Segmentation by Patch-Level and WSI-Level Contrastive Learning

arXiv: https://arxiv.org/abs/2508.07539 · HTML: https://mlsanity.com/paper/2508.07539/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 17 of its 20 references that are in the map.
- First posted on arXiv 11 Aug 2025.

## Builds on (most cited first, 17 of 17)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Supervised Contrastive Learning](https://mlsanity.com/paper/2004.11362/) (2020)
- [Learning to Generalize: Meta-Learning for Domain Generalization](https://mlsanity.com/paper/1710.03463/) (2017)
- [Domain Generalization via Invariant Feature Representation](https://mlsanity.com/paper/1301.2115/) (2013)
- [Self-Challenging Improves Cross-Domain Generalization](https://mlsanity.com/paper/2007.02454/) (2020)
- [Domain Generalization Using a Mixture of Multiple Latent Domains](https://mlsanity.com/paper/1911.07661/) (2019)
- [Learning to Diversify for Single Domain Generalization](https://mlsanity.com/paper/2108.11726/) (2021)
- [Learning to Generalize Unseen Domains via Memory-based Multi-Source Meta-Learning for Person Re-Identification](https://mlsanity.com/paper/2012.00417/) (2020)
- [Progressive Domain Expansion Network for Single Domain Generalization](https://mlsanity.com/paper/2103.16050/) (2021)
- [Adversarially Adaptive Normalization for Single Domain Generalization](https://mlsanity.com/paper/2106.01899/) (2021)
- [Task-specific Fine-tuning via Variational Information Bottleneck for Weakly-supervised Pathology Whole Slide Image Classification](https://mlsanity.com/paper/2303.08446/) (2023)
- [Adversarial Invariant Feature Learning with Accuracy Constraint for Domain Generalization](https://mlsanity.com/paper/1904.12543/) (2019)
- [Semi-Supervised Domain Generalization with Stochastic StyleMatch](https://mlsanity.com/paper/2106.00592/) (2021)
- [Adaptive Weighting Multi-Field-of-View CNN for Semantic Segmentation in Pathology](https://mlsanity.com/paper/1904.06040/) (2019)
- [Rethinking Domain Generalization Baselines](https://mlsanity.com/paper/2101.09060/) (2021)
- [Single-domain Generalization in Medical Image Segmentation via Test-time Adaptation from Shape Dictionary](https://mlsanity.com/paper/2206.14467/) (2022)

## Built on by (most cited first, 1 of 1)

- [One-Slide Calibration of Pathology Foundation Models](https://mlsanity.com/paper/2610.08944/) (2026)

## Abstract (arXiv)

In this paper, we address domain shifts in pathological images by focusing on shifts within whole slide images~(WSIs), such as patient characteristics and tissue thickness, rather than shifts between hospitals. Traditional approaches rely on multi-hospital data, but data collection challenges often make this impractical. Therefore, the proposed domain generalization method captures and leverages intra-hospital domain shifts by clustering WSI-level features from non-tumor regions and treating these clusters as domains. To mitigate domain shift, we apply contrastive learning to reduce feature gaps between WSI pairs from different clusters. The proposed method introduces a two-stage contrastive learning approach WSI-level and patch-level contrastive learning to minimize these gaps effectively.