# Retrieval Augmented Large Language Model System for Comprehensive Drug Contraindications

arXiv: https://arxiv.org/abs/2508.06145 · HTML: https://mlsanity.com/paper/2508.06145/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 11 of its 31 references that are in the map.
- First posted on arXiv 8 Aug 2025.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)

## Builds on (most cited first, 11 of 11)

- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [MedGemma Technical Report](https://mlsanity.com/paper/2507.05201/) (2025)
- [A Comprehensive Survey on Vector Database: Storage and Retrieval Technique, Challenge](https://mlsanity.com/paper/2310.11703/) (2023)
- [Survey of different Large Language Model Architectures: Trends, Benchmarks, and Challenges](https://mlsanity.com/paper/2412.03220/) (2024)
- [LLM-MedQA: Enhancing Medical Question Answering through Case Studies in Large Language Models](https://mlsanity.com/paper/2501.05464/) (2024)
- [A Modular Approach for Clinical SLMs Driven by Synthetic Data with Pre-Instruction Tuning, Model Merging, and Clinical-Tasks Alignment](https://mlsanity.com/paper/2505.10717/) (2025)
- [MALADE: Orchestration of LLM-powered Agents with Retrieval Augmented Generation for Pharmacovigilance](https://mlsanity.com/paper/2408.01869/) (2024)
- [MedLM: Exploring Language Models for Medical Question Answering Systems](https://mlsanity.com/paper/2401.11389/) (2024)

## Abstract (arXiv)

The versatility of large language models (LLMs) has been explored across various sectors, but their application in healthcare poses challenges, particularly in the domain of pharmaceutical contraindications where accurate and reliable information is required. This study enhances the capability of LLMs to address contraindications effectively by implementing a Retrieval Augmented Generation (RAG) pipeline. Utilizing OpenAI's GPT-4o-mini as the base model, and the text-embedding-3-small model for embeddings, our approach integrates Langchain to orchestrate a hybrid retrieval system with re-ranking. This system leverages Drug Utilization Review (DUR) data from public databases, focusing on contraindications for specific age groups, pregnancy, and concomitant drug use. The dataset includes 300 question-answer pairs across three categories, with baseline model accuracy ranging from 0.49 to 0.57. Post-integration of the RAG pipeline, we observed a significant improvement in model accuracy, achieving rates of 0.94, 0.87, and 0.89 for contraindications related to age groups, pregnancy, and concomitant drug use, respectively. The results indicate that augmenting LLMs with a RAG framework can substantially reduce uncertainty in prescription and drug intake decisions by providing more precise and reliable drug contraindication information.