# Open-Source Agentic Hybrid RAG Framework for Scientific Literature Review

arXiv: https://arxiv.org/abs/2508.05660 · HTML: https://mlsanity.com/paper/2508.05660/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Placed in Agentic RAG, agents and memory, one of 15 directions in Retrieval-augmented generation.
- Builds on 13 of its 38 references that are in the map.
- First posted on arXiv 30 Jul 2025.

## Placed in

- Retrieval-augmented generation / [Agentic RAG, agents and memory](https://mlsanity.com/rag/agentic-rag-agents-and-memory/)
- LLM agents and tool use / [Web, search, and research agents](https://mlsanity.com/agents/web-search-and-research-agents/)

## Builds on (most cited first, 13 of 13)

- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Deep reinforcement learning from human preferences](https://mlsanity.com/paper/1706.03741/) (2017)
- [Learning to summarize from human feedback](https://mlsanity.com/paper/2009.01325/) (2020)
- [Agentic Retrieval-Augmented Generation: A Survey on Agentic RAG](https://mlsanity.com/paper/2501.09136/) (2025)
- [PaperQA: Retrieval-Augmented Generative Agent for Scientific Research](https://mlsanity.com/paper/2312.07559/) (2023)
- [HybridRAG: Integrating Knowledge Graphs and Vector Retrieval Augmented Generation for Efficient Information Extraction](https://mlsanity.com/paper/2408.04948/) (2024)
- [Uncertainty Estimation and Quantification for LLMs: A Simple Supervised Approach](https://mlsanity.com/paper/2404.15993/) (2024)
- [Growth rates of modern science: A latent piecewise growth curve approach to model publication numbers from established and new literature databases](https://mlsanity.com/paper/2012.07675/) (2020)
- [DualRAG: A Dual-Process Approach to Integrate Reasoning and Retrieval for Multi-Hop Question Answering](https://mlsanity.com/paper/2504.18243/) (2025)
- [Relevance Filtering for Embedding-based Retrieval](https://mlsanity.com/paper/2408.04887/) (2024)
- [Open Research Knowledge Graph:A System Walkthrough](https://mlsanity.com/paper/2206.01439/) (2022)
- [PolyG: Adaptive Graph Traversal for Diverse GraphRAG Questions](https://mlsanity.com/paper/2504.02112/) (2025)

## Built on by (most cited first, 2 of 2)

- [IntrAgent: An LLM Agent for Content-Grounded Information Retrieval through Literature Review](https://mlsanity.com/paper/2604.22861/) (2026)
- [HVM-GraphRAG: Holistic-View Multimodal Graph Retrieval-Augmented Generation on Complex Document](https://mlsanity.com/paper/2607.24861/) (2026)

## Abstract (arXiv)

The surge in scientific publications challenges traditional review methods, demanding tools that integrate structured metadata with full-text analysis. Hybrid Retrieval Augmented Generation (RAG) systems, combining graph queries with vector search offer promise but are typically static, rely on proprietary tools, and lack uncertainty estimates. We present an agentic approach that encapsulates the hybrid RAG pipeline within an autonomous agent capable of (1) dynamically selecting between GraphRAG and VectorRAG for each query, (2) adapting instruction-tuned generation in real time to researcher needs, and (3) quantifying uncertainty during inference. This dynamic orchestration improves relevance, reduces hallucinations, and promotes reproducibility. Our pipeline ingests bibliometric open-access data from PubMed, arXiv, and Google Scholar APIs, builds a Neo4j citation-based knowledge graph (KG), and embeds full-text PDFs into a FAISS vector store (VS) using the all-MiniLM-L6-v2 model. A Llama-3.3-70B agent selects GraphRAG (translating queries to Cypher for KG) or VectorRAG (combining sparse and dense retrieval with re-ranking). Instruction tuning refines domain-specific generation, and bootstrapped evaluation yields standard deviation for evaluation metrics. On synthetic benchmarks mimicking real-world queries, the Instruction-Tuned Agent with Direct Preference Optimization (DPO) outperforms the baseline, achieving a gain of 0.63 in VS Context Recall and a 0.56 gain in overall Context Precision. Additional gains include 0.24 in VS Faithfulness, 0.12 in both VS Precision and KG Answer Relevance, 0.11 in overall Faithfulness score, 0.05 in KG Context Recall, and 0.04 in both VS Answer Relevance and overall Precision. These results highlight the system's improved reasoning over heterogeneous sources and establish a scalable framework for autonomous, agentic scientific discovery.