# MM2CT: MR-to-CT translation for multi-modal image fusion with mamba

arXiv: https://arxiv.org/abs/2508.05476 · HTML: https://mlsanity.com/paper/2508.05476/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 17 of its 28 references that are in the map.
- First posted on arXiv 7 Aug 2025.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 17 of 17)

- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Perceptual Losses for Real-Time Style Transfer and Super-Resolution](https://mlsanity.com/paper/1603.08155/) (2016)
- [VMamba: Visual State Space Model](https://mlsanity.com/paper/2401.10166/) (2024)
- [Unsupervised Medical Image Translation with Adversarial Diffusion Models](https://mlsanity.com/paper/2207.08208/) (2022)
- [ResViT: Residual vision transformers for multi-modal medical image synthesis](https://mlsanity.com/paper/2106.16031/) (2021)
- [MedGAN: Medical Image Translation using GANs](https://mlsanity.com/paper/1806.06397/) (2018)
- [FusionMamba: Dynamic Feature Enhancement for Multimodal Image Fusion with Mamba](https://mlsanity.com/paper/2404.09498/) (2024)
- [A Survey of Mamba](https://mlsanity.com/paper/2408.01129/) (2024)
- [DiamondGAN: Unified Multi-Modal Generative Adversarial Networks for MRI Sequences Synthesis](https://mlsanity.com/paper/1904.12894/) (2019)
- [MambaDFuse: A Mamba-based Dual-phase Model for Multi-modality Image Fusion](https://mlsanity.com/paper/2404.08406/) (2024)
- [I2I-Mamba: Multi-modal medical image synthesis via selective state space modeling](https://mlsanity.com/paper/2405.14022/) (2024)
- [Structure-Preserving Synthesis: MaskGAN for Unpaired MR-CT Translation](https://mlsanity.com/paper/2307.16143/) (2023)
- [Multimodal Multi-Head Convolutional Attention with Various Kernel Sizes for Medical Image Super-Resolution](https://mlsanity.com/paper/2204.04218/) (2022)
- [A New Perspective on Stabilizing GANs training: Direct Adversarial Training](https://mlsanity.com/paper/2008.09041/) (2020)
- [ASI-Seg: Audio-Driven Surgical Instrument Segmentation with Surgeon Intention Understanding](https://mlsanity.com/paper/2407.19435/) (2024)
- [Transforming Surgical Interventions with Embodied Intelligence for Ultrasound Robotics](https://mlsanity.com/paper/2406.12651/) (2024)
- [Towards Multi-modality Fusion and Prototype-based Feature Refinement for Clinically Significant Prostate Cancer Classification in Transrectal Ultrasound](https://mlsanity.com/paper/2406.14069/) (2024)

## Abstract (arXiv)

Magnetic resonance (MR)-to-computed tomography (CT) translation offers significant advantages, including the elimination of radiation exposure associated with CT scans and the mitigation of imaging artifacts caused by patient motion. The existing approaches are based on single-modality MR-to-CT translation, with limited research exploring multimodal fusion. To address this limitation, we introduce Multi-modal MR to CT (MM2CT) translation method by leveraging multimodal T1- and T2-weighted MRI data, an innovative Mamba-based framework for multi-modal medical image synthesis. Mamba effectively overcomes the limited local receptive field in CNNs and the high computational complexity issues in Transformers. MM2CT leverages this advantage to maintain long-range dependencies modeling capabilities while achieving multi-modal MR feature integration. Additionally, we incorporate a dynamic local convolution module and a dynamic enhancement module to improve MRI-to-CT synthesis. The experiments on a public pelvis dataset demonstrate that MM2CT achieves state-of-the-art performance in terms of Structural Similarity Index Measure (SSIM) and Peak Signal-to-Noise Ratio (PSNR). Our code is publicly available at https://github.com/Gots-ch/MM2CT.