# M3HL: Mutual Mask Mix with High-Low Level Feature Consistency for Semi-Supervised Medical Image Segmentation

arXiv: https://arxiv.org/abs/2508.03752 · HTML: https://mlsanity.com/paper/2508.03752/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 21 references that are in the map.
- First posted on arXiv 4 Aug 2025.

## Builds on (most cited first, 15 of 15)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [Semi-Supervised Semantic Segmentation with Cross Pseudo Supervision](https://mlsanity.com/paper/2106.01226/) (2021)
- [Uncertainty-aware Self-ensembling Model for Semi-supervised 3D Left Atrium Segmentation](https://mlsanity.com/paper/1907.07034/) (2019)
- [Semi-supervised Medical Image Segmentation through Dual-task Consistency](https://mlsanity.com/paper/2009.04448/) (2020)
- [Shape-aware Semi-supervised 3D Semantic Segmentation for Medical Images](https://mlsanity.com/paper/2007.10732/) (2020)
- [Bidirectional Copy-Paste for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2305.00673/) (2023)
- [Perturbed and Strict Mean Teachers for Semi-supervised Semantic Segmentation](https://mlsanity.com/paper/2111.12903/) (2021)
- [Mutual Consistency Learning for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2109.09960/) (2021)
- [Semi-Supervised Medical Image Segmentation via Cross Teaching between CNN and Transformer](https://mlsanity.com/paper/2112.04894/) (2021)
- [Exploring Smoothness and Class-Separation for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2203.01324/) (2022)
- [Adaptive Bidirectional Displacement for Semi-Supervised Medical Image Segmentation](https://mlsanity.com/paper/2405.00378/) (2024)
- [Alternate Diverse Teaching for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2311.17325/) (2023)

## Abstract (arXiv)

Data augmentation methods inspired by CutMix have demonstrated significant potential in recent semi-supervised medical image segmentation tasks. However, these approaches often apply CutMix operations in a rigid and inflexible manner, while paying insufficient attention to feature-level consistency constraints. In this paper, we propose a novel method called Mutual Mask Mix with High-Low level feature consistency (M3HL) to address the aforementioned challenges, which consists of two key components: 1) M3: An enhanced data augmentation operation inspired by the masking strategy from Masked Image Modeling (MIM), which advances conventional CutMix through dynamically adjustable masks to generate spatially complementary image pairs for collaborative training, thereby enabling effective information fusion between labeled and unlabeled images. 2) HL: A hierarchical consistency regularization framework that enforces high-level and low-level feature consistency between unlabeled and mixed images, enabling the model to better capture discriminative feature representations.Our method achieves state-of-the-art performance on widely adopted medical image segmentation benchmarks including the ACDC and LA datasets. Source code is available at https://github.com/PHPJava666/M3HL