# MetaScope: Optics-Driven Neural Network for Ultra-Micro Metalens Endoscopy

arXiv: https://arxiv.org/abs/2508.03596 · HTML: https://mlsanity.com/paper/2508.03596/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 45 of its 108 references that are in the map.
- First posted on arXiv 5 Aug 2025.

## Builds on (most cited first, 30 of 45)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [SegFormer: Simple and Efficient Design for Semantic Segmentation with Transformers](https://mlsanity.com/paper/2105.15203/) (2021)
- [Masked-attention Mask Transformer for Universal Image Segmentation](https://mlsanity.com/paper/2112.01527/) (2021)
- [SwinIR: Image Restoration Using Swin Transformer](https://mlsanity.com/paper/2108.10257/) (2021)
- [Restormer: Efficient Transformer for High-Resolution Image Restoration](https://mlsanity.com/paper/2111.09881/) (2021)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Unified Perceptual Parsing for Scene Understanding](https://mlsanity.com/paper/1807.10221/) (2018)
- [Accurate Image Super-Resolution Using Very Deep Convolutional Networks](https://mlsanity.com/paper/1511.04587/) (2015)
- [Simple Baselines for Image Restoration](https://mlsanity.com/paper/2204.04676/) (2022)
- [Kvasir-SEG: A Segmented Polyp Dataset](https://mlsanity.com/paper/1911.07069/) (2019)
- [Medical SAM Adapter: Adapting Segment Anything Model for Medical Image Segmentation](https://mlsanity.com/paper/2304.12620/) (2023)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [MambaIR: A Simple Baseline for Image Restoration with State-Space Model](https://mlsanity.com/paper/2402.15648/) (2024)
- [DiffBIR: Towards Blind Image Restoration with Generative Diffusion Prior](https://mlsanity.com/paper/2308.15070/) (2023)
- [SegNeXt: Rethinking Convolutional Attention Design for Semantic Segmentation](https://mlsanity.com/paper/2209.08575/) (2022)
- [Medical Image Segmentation Review: The success of U-Net](https://mlsanity.com/paper/2211.14830/) (2022)
- [UNeXt: MLP-based Rapid Medical Image Segmentation Network](https://mlsanity.com/paper/2203.04967/) (2022)
- [U-KAN Makes Strong Backbone for Medical Image Segmentation and Generation](https://mlsanity.com/paper/2406.02918/) (2024)
- [Learn2Reg: comprehensive multi-task medical image registration challenge, dataset and evaluation in the era of deep learning](https://mlsanity.com/paper/2112.04489/) (2021)
- [SIGMA: Semantic-complete Graph Matching for Domain Adaptive Object Detection](https://mlsanity.com/paper/2203.06398/) (2022)
- [Endora: Video Generation Models as Endoscopy Simulators](https://mlsanity.com/paper/2403.11050/) (2024)
- [Kvasir-Instrument: Diagnostic and therapeutic tool segmentation dataset in gastrointestinal endoscopy](https://mlsanity.com/paper/2011.08065/) (2020)
- [Bidirectional Multi-Scale Implicit Neural Representations for Image Deraining](https://mlsanity.com/paper/2404.01547/) (2024)
- [Procedure-Aware Surgical Video-language Pretraining with Hierarchical Knowledge Augmentation](https://mlsanity.com/paper/2410.00263/) (2024)

## Abstract (arXiv)

Miniaturized endoscopy has advanced accurate visual perception within the human body. Prevailing research remains limited to conventional cameras employing convex lenses, where the physical constraints with millimetre-scale thickness impose serious impediments on the micro-level clinical. Recently, with the emergence of meta-optics, ultra-micro imaging based on metalenses (micron-scale) has garnered great attention, serving as a promising solution. However, due to the physical difference of metalens, there is a large gap in data acquisition and algorithm research. In light of this, we aim to bridge this unexplored gap, advancing the novel metalens endoscopy. First, we establish datasets for metalens endoscopy and conduct preliminary optical simulation, identifying two derived optical issues that physically adhere to strong optical priors. Second, we propose MetaScope, a novel optics-driven neural network tailored for metalens endoscopy driven by physical optics. MetaScope comprises two novel designs: Optics-informed Intensity Adjustment (OIA), rectifying intensity decay by learning optical embeddings, and Optics-informed Chromatic Correction (OCC), mitigating chromatic aberration by learning spatial deformations informed by learned Point Spread Function (PSF) distributions. To enhance joint learning, we further deploy a gradient-guided distillation to transfer knowledge from the foundational model adaptively. Extensive experiments demonstrate that MetaScope not only outperforms state-of-the-art methods in both metalens segmentation and restoration but also achieves impressive generalized ability in real biomedical scenes.