# Nexus-INR: Diverse Knowledge-guided Arbitrary-Scale Multimodal Medical Image Super-Resolution

arXiv: https://arxiv.org/abs/2508.03073 · HTML: https://mlsanity.com/paper/2508.03073/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 14 of its 23 references that are in the map.
- First posted on arXiv 5 Aug 2025.

## Builds on (most cited first, 14 of 14)

- [Implicit Neural Representations with Periodic Activation Functions](https://mlsanity.com/paper/2006.09661/) (2020)
- [Fourier Features Let Networks Learn High Frequency Functions in Low Dimensional Domains](https://mlsanity.com/paper/2006.10739/) (2020)
- [Photo-Realistic Single Image Super-Resolution Using a Generative Adversarial Network](https://mlsanity.com/paper/1609.04802/) (2016)
- [Residual Dense Network for Image Super-Resolution](https://mlsanity.com/paper/1802.08797/) (2018)
- [Learning Continuous Image Representation with Local Implicit Image Function](https://mlsanity.com/paper/2012.09161/) (2020)
- [Learned Initializations for Optimizing Coordinate-Based Neural Representations](https://mlsanity.com/paper/2012.02189/) (2020)
- [Multi-modal Learning with Missing Modality via Shared-Specific Feature Modelling](https://mlsanity.com/paper/2307.14126/) (2023)
- [An Arbitrary Scale Super-Resolution Approach for 3D MR Images via Implicit Neural Representation](https://mlsanity.com/paper/2110.14476/) (2021)
- [Brain MRI Super Resolution Using 3D Deep Densely Connected Neural Networks](https://mlsanity.com/paper/1801.02728/) (2018)
- [Multi-Contrast Super-Resolution MRI Through a Progressive Network](https://mlsanity.com/paper/1908.01612/) (2019)
- [SAINT: Spatially Aware Interpolation NeTwork for Medical Slice Synthesis](https://mlsanity.com/paper/2001.00704/) (2020)
- [CycleINR: Cycle Implicit Neural Representation for Arbitrary-Scale Volumetric Super-Resolution of Medical Data](https://mlsanity.com/paper/2404.04878/) (2024)
- [Semantic Segmentation Prior for Diffusion-Based Real-World Super-Resolution](https://mlsanity.com/paper/2412.02960/) (2024)
- [I3Net: Inter-Intra-slice Interpolation Network for Medical Slice Synthesis](https://mlsanity.com/paper/2405.02857/) (2024)

## Abstract (arXiv)

Arbitrary-resolution super-resolution (ARSR) provides crucial flexibility for medical image analysis by adapting to diverse spatial resolutions. However, traditional CNN-based methods are inherently ill-suited for ARSR, as they are typically designed for fixed upsampling factors. While INR-based methods overcome this limitation, they still struggle to effectively process and leverage multi-modal images with varying resolutions and details. In this paper, we propose Nexus-INR, a Diverse Knowledge-guided ARSR framework, which employs varied information and downstream tasks to achieve high-quality, adaptive-resolution medical image super-resolution. Specifically, Nexus-INR contains three key components. A dual-branch encoder with an auxiliary classification task to effectively disentangle shared anatomical structures and modality-specific features; a knowledge distillation module using cross-modal attention that guides low-resolution modality reconstruction with high-resolution reference, enhanced by self-supervised consistency loss; an integrated segmentation module that embeds anatomical semantics to improve both reconstruction quality and downstream segmentation performance. Experiments on the BraTS2020 dataset for both super-resolution and downstream segmentation demonstrate that Nexus-INR outperforms state-of-the-art methods across various metrics.