# Measuring Dependencies between Biological Signals with Self-supervision, and its Limitations

arXiv: https://arxiv.org/abs/2508.02703 · HTML: https://mlsanity.com/paper/2508.02703/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 7 of its 52 references that are in the map.
- First posted on arXiv 29 Jul 2025.

## Builds on (most cited first, 7 of 7)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [An Empirical Evaluation of Generic Convolutional and Recurrent Networks for Sequence Modeling](https://mlsanity.com/paper/1803.01271/) (2018)
- [Time Series Classification from Scratch with Deep Neural Networks: A Strong Baseline](https://mlsanity.com/paper/1611.06455/) (2016)
- [Self-Supervised Contrastive Pre-Training For Time Series via Time-Frequency Consistency](https://mlsanity.com/paper/2206.08496/) (2022)
- [Foundation Models for Time Series Analysis: A Tutorial and Survey](https://mlsanity.com/paper/2403.14735/) (2024)
- [Universality of Deep Convolutional Neural Networks](https://mlsanity.com/paper/1805.10769/) (2018)

## Abstract (arXiv)

Measuring the statistical dependence between observed signals is a primary tool for scientific discovery. However, biological systems often exhibit complex non-linear interactions that currently cannot be captured without a priori knowledge regarding the nature of dependence. We introduce a self-supervised approach, concurrence, which is inspired by the observation that if two signals are dependent, then one should be able to distinguish between temporally aligned vs. misaligned segments extracted from them. Experiments with fMRI, physiological and behavioral signals show that, to our knowledge, concurrence is the first approach that can expose relationships across such a wide spectrum of signals and extract scientifically relevant differences without ad-hoc parameter tuning or reliance on a priori information, providing a potent tool for scientific discoveries across fields. However, dependencies caused by extraneous factors remain an open problem, thus researchers should validate that exposed relationships truly pertain to the question(s) of interest.