# Rep-GLS: Report-Guided Generalized Label Smoothing for Robust Disease Detection

arXiv: https://arxiv.org/abs/2508.02495 · HTML: https://mlsanity.com/paper/2508.02495/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 20 of its 36 references that are in the map.
- First posted on arXiv 4 Aug 2025.

## Builds on (most cited first, 20 of 20)

- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [On Calibration of Modern Neural Networks](https://mlsanity.com/paper/1706.04599/) (2017)
- [When Does Label Smoothing Help?](https://mlsanity.com/paper/1906.02629/) (2019)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [MIMIC-CXR-JPG, a large publicly available database of labeled chest radiographs](https://mlsanity.com/paper/1901.07042/) (2019)
- [Robust Loss Functions under Label Noise for Deep Neural Networks](https://mlsanity.com/paper/1712.09482/) (2017)
- [CheXbert: Combining Automatic Labelers and Expert Annotations for Accurate Radiology Report Labeling Using BERT](https://mlsanity.com/paper/2004.09167/) (2020)
- [Deep learning with noisy labels: exploring techniques and remedies in medical image analysis](https://mlsanity.com/paper/1912.02911/) (2019)
- [CheXclusion: Fairness gaps in deep chest X-ray classifiers](https://mlsanity.com/paper/2003.00827/) (2020)
- [Learning From Noisy Labels By Regularized Estimation Of Annotator Confusion](https://mlsanity.com/paper/1902.03680/) (2019)
- [To Smooth or Not? When Label Smoothing Meets Noisy Labels](https://mlsanity.com/paper/2106.04149/) (2021)
- [Class2Simi: A Noise Reduction Perspective on Learning with Noisy Labels](https://mlsanity.com/paper/2006.07831/) (2020)
- [Noise-Consistent Siamese-Diffusion for Medical Image Synthesis and Segmentation](https://mlsanity.com/paper/2505.06068/) (2025)
- [Anatomy-XNet: An Anatomy Aware Convolutional Neural Network for Thoracic Disease Classification in Chest X-rays](https://mlsanity.com/paper/2106.05915/) (2021)
- [BoMD: Bag of Multi-label Descriptors for Noisy Chest X-ray Classification](https://mlsanity.com/paper/2203.01937/) (2022)
- [Interpreting chest X-rays via CNNs that exploit hierarchical disease dependencies and uncertainty labels](https://mlsanity.com/paper/1911.06475/) (2019)
- [MvHo-IB: Multi-View Higher-Order Information Bottleneck for Brain Disorder Diagnosis](https://mlsanity.com/paper/2507.02847/) (2025)
- [Label-noise-tolerant medical image classification via self-attention and self-supervised learning](https://mlsanity.com/paper/2306.09718/) (2023)
- [Contrastive-Based Deep Embeddings for Label Noise-Resilient Histopathology Image Classification](https://mlsanity.com/paper/2404.07605/) (2024)

## Built on by (most cited first, 1 of 1)

- [Hierarchical Dual-Strategy Unlearning for Biomedical and Healthcare Intelligence Using Imperfect and Privacy-Sensitive Medical Data](https://mlsanity.com/paper/2511.19498/) (2025)

## Abstract (arXiv)

Unlike nature image classification where groundtruth label is explicit and of no doubt, physicians commonly interpret medical image conditioned on certainty like using phrase "probable" or "likely". Existing medical image datasets either simply overlooked the nuance and polarise into binary label. Here, we propose a novel framework that leverages a Large Language Model (LLM) to directly mine medical reports to utilise the uncertainty relevant expression for supervision signal. At first, we collect uncertainty keywords from medical reports. Then, we use Qwen-3 4B to identify the textual uncertainty and map them into an adaptive Generalized Label Smoothing (GLS) rate. This rate allows our model to treat uncertain labels not as errors, but as informative signals, effectively incorporating expert skepticism into the training process. We establish a new clinical expert uncertainty-aware benchmark to rigorously evaluate this problem. Experiments demonstrate that our approach significantly outperforms state-of-the-art methods in medical disease detection. The curated uncertainty words database, code, and benchmark will be made publicly available upon acceptance.