# Enhancing Zero-Shot Brain Tumor Subtype Classification via Fine-Grained Patch-Text Alignment

arXiv: https://arxiv.org/abs/2508.01602 · HTML: https://mlsanity.com/paper/2508.01602/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Builds on 84 of its 160 references that are in the map.
- First posted on arXiv 3 Aug 2025.

## Builds on (most cited first, 30 of 84)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [The Llama 3 Herd of Models](https://mlsanity.com/paper/2407.21783/) (2024)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [BLIP: Bootstrapping Language-Image Pre-training for Unified Vision-Language Understanding and Generation](https://mlsanity.com/paper/2201.12086/) (2022)
- [Scaling Up Visual and Vision-Language Representation Learning With Noisy Text Supervision](https://mlsanity.com/paper/2102.05918/) (2021)
- [Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context](https://mlsanity.com/paper/2403.05530/) (2024)
- [Learning to Prompt for Vision-Language Models](https://mlsanity.com/paper/2109.01134/) (2021)
- [Visual Prompt Tuning](https://mlsanity.com/paper/2203.12119/) (2022)
- [Conditional Prompt Learning for Vision-Language Models](https://mlsanity.com/paper/2203.05557/) (2022)
- [CoCa: Contrastive Captioners are Image-Text Foundation Models](https://mlsanity.com/paper/2205.01917/) (2022)
- [Florence: A New Foundation Model for Computer Vision](https://mlsanity.com/paper/2111.11432/) (2021)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [MaPLe: Multi-modal Prompt Learning](https://mlsanity.com/paper/2210.03117/) (2022)
- [FLAVA: A Foundational Language And Vision Alignment Model](https://mlsanity.com/paper/2112.04482/) (2021)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [Test-Time Prompt Tuning for Zero-Shot Generalization in Vision-Language Models](https://mlsanity.com/paper/2209.07511/) (2022)
- [Scaling Vision Transformers to Gigapixel Images via Hierarchical Self-Supervised Learning](https://mlsanity.com/paper/2206.02647/) (2022)
- [Prompt-aligned Gradient for Prompt Tuning](https://mlsanity.com/paper/2205.14865/) (2022)
- [Visual Classification via Description from Large Language Models](https://mlsanity.com/paper/2210.07183/) (2022)
- [What does a platypus look like? Generating customized prompts for zero-shot image classification](https://mlsanity.com/paper/2209.03320/) (2022)
- [TF-ICON: Diffusion-Based Training-Free Cross-Domain Image Composition](https://mlsanity.com/paper/2307.12493/) (2023)
- [Multimodal Whole Slide Foundation Model for Pathology](https://mlsanity.com/paper/2411.19666/) (2024)
- [Patch-based Convolutional Neural Network for Whole Slide Tissue Image Classification](https://mlsanity.com/paper/1504.07947/) (2015)
- [Benchmarking Self-Supervised Learning on Diverse Pathology Datasets](https://mlsanity.com/paper/2212.04690/) (2022)
- [Visual Language Pretrained Multiple Instance Zero-Shot Transfer for Histopathology Images](https://mlsanity.com/paper/2306.07831/) (2023)
- [BRACS: A Dataset for BReAst Carcinoma Subtyping in H&E Histology Images](https://mlsanity.com/paper/2111.04740/) (2021)

## Built on by (most cited first, 4 of 4)

- [SSCM: A Spatial-Semantic Consistent Model for Multi-Contrast MRI Super-Resolution](https://mlsanity.com/paper/2509.18593/) (2025)
- [SemaMIL: Semantic-Aware Multiple Instance Learning with Retrieval-Guided State Space Modeling for Whole Slide Images](https://mlsanity.com/paper/2509.00442/) (2025)
- [DeRainMamba: A Frequency-Aware State Space Model with Detail Enhancement for Image Deraining](https://mlsanity.com/paper/2510.06746/) (2025)
- [ReconMIL: Synergizing Latent Space Reconstruction with Bi-Stream Mamba for Whole Slide Image Analysis](https://mlsanity.com/paper/2603.19925/) (2026)

## Abstract (arXiv)

The fine-grained classification of brain tumor subtypes from histopathological whole slide images is highly challenging due to subtle morphological variations and the scarcity of annotated data. Although vision-language models have enabled promising zero-shot classification, their ability to capture fine-grained pathological features remains limited, resulting in suboptimal subtype discrimination. To address these challenges, we propose the Fine-Grained Patch Alignment Network (FG-PAN), a novel zero-shot framework tailored for digital pathology. FG-PAN consists of two key modules: (1) a local feature refinement module that enhances patch-level visual features by modeling spatial relationships among representative patches, and (2) a fine-grained text description generation module that leverages large language models to produce pathology-aware, class-specific semantic prototypes. By aligning refined visual features with LLM-generated fine-grained descriptions, FG-PAN effectively increases class separability in both visual and semantic spaces. Extensive experiments on multiple public pathology datasets, including EBRAINS and TCGA, demonstrate that FG-PAN achieves state-of-the-art performance and robust generalization in zero-shot brain tumor subtype classification.