# Explainable Image Classification with Reduced Overconfidence for Tissue Characterisation

arXiv: https://arxiv.org/abs/2507.23709 · HTML: https://mlsanity.com/paper/2507.23709/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 28 references that are in the map.
- First posted on arXiv 31 Jul 2025.

## Builds on (most cited first, 15 of 15)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [PyTorch: An Imperative Style, High-Performance Deep Learning Library](https://mlsanity.com/paper/1912.01703/) (2019)
- [Explaining and Harnessing Adversarial Examples](https://mlsanity.com/paper/1412.6572/) (2014)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [MobileNetV2: Inverted Residuals and Linear Bottlenecks](https://mlsanity.com/paper/1801.04381/) (2018)
- [Dropout as a Bayesian Approximation: Representing Model Uncertainty in Deep Learning](https://mlsanity.com/paper/1506.02142/) (2015)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [Visualizing and Understanding Convolutional Networks](https://mlsanity.com/paper/1311.2901/) (2013)
- [RISE: Randomized Input Sampling for Explanation of Black-box Models](https://mlsanity.com/paper/1806.07421/) (2018)
- [Score-CAM: Score-Weighted Visual Explanations for Convolutional Neural Networks](https://mlsanity.com/paper/1910.01279/) (2019)
- [Weight Uncertainty in Neural Networks](https://mlsanity.com/paper/1505.05424/) (2015)
- [Smooth Grad-CAM++: An Enhanced Inference Level Visualization Technique for Deep Convolutional Neural Network Models](https://mlsanity.com/paper/1908.01224/) (2019)
- [Revisiting The Evaluation of Class Activation Mapping for Explainability: A Novel Metric and Experimental Analysis](https://mlsanity.com/paper/2104.10252/) (2021)
- [Dropout as a Bayesian Approximation: Appendix](https://mlsanity.com/paper/1506.02157/) (2015)
- [Identifying Spurious Correlations and Correcting them with an Explanation-based Learning](https://mlsanity.com/paper/2211.08285/) (2022)

## Abstract (arXiv)

The deployment of Machine Learning models intraoperatively for tissue characterisation can assist decision making and guide safe tumour resections. For image classification models, pixel attribution methods are popular to infer explainability. However, overconfidence in deep learning model's predictions translates to overconfidence in pixel attribution. In this paper, we propose the first approach which incorporates risk estimation into a pixel attribution method for improved image classification explainability. The proposed method iteratively applies a classification model with a pixel attribution method to create a volume of PA maps. This volume is used for the first time, to generate a pixel-wise distribution of PA values. We introduce a method to generate an enhanced PA map by estimating the expectation values of the pixel-wise distributions. In addition, the coefficient of variation (CV) is used to estimate pixel-wise risk of this enhanced PA map. Hence, the proposed method not only provides an improved PA map but also produces an estimation of risk on the output PA values. Performance evaluation on probe-based Confocal Laser Endomicroscopy (pCLE) data and ImageNet verifies that our improved explainability method outperforms the state-of-the-art.