# How Far Are AI Scientists from Changing the World?

arXiv: https://arxiv.org/abs/2507.23276 · HTML: https://mlsanity.com/paper/2507.23276/

## Key facts

- Cited by 15 papers in the map (data through 14 Oct 2026).
- Builds on 143 of its 200 references that are in the map.
- First posted on arXiv 31 Jul 2025.

## Builds on (most cited first, 30 of 143)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [Chain-of-Thought Prompting Elicits Reasoning in Large Language Models](https://mlsanity.com/paper/2201.11903/) (2022)
- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Overcoming catastrophic forgetting in neural networks](https://mlsanity.com/paper/1612.00796/) (2016)
- [Reflexion: Language Agents with Verbal Reinforcement Learning](https://mlsanity.com/paper/2303.11366/) (2023)
- [Self-Refine: Iterative Refinement with Self-Feedback](https://mlsanity.com/paper/2303.17651/) (2023)
- [SWE-bench: Can Language Models Resolve Real-World GitHub Issues?](https://mlsanity.com/paper/2310.06770/) (2023)
- [Constitutional AI: Harmlessness from AI Feedback](https://mlsanity.com/paper/2212.08073/) (2022)
- [Retrieval-Augmented Generation for Large Language Models: A Survey](https://mlsanity.com/paper/2312.10997/) (2023)
- [BioBERT: a pre-trained biomedical language representation model for biomedical text mining](https://mlsanity.com/paper/1901.08746/) (2019)
- [A Survey on Hallucination in Large Language Models: Principles, Taxonomy, Challenges, and Open Questions](https://mlsanity.com/paper/2311.05232/) (2023)
- [SciBERT: A Pretrained Language Model for Scientific Text](https://mlsanity.com/paper/1903.10676/) (2019)
- [The AI Scientist: Towards Fully Automated Open-Ended Scientific Discovery](https://mlsanity.com/paper/2408.06292/) (2024)
- [Domain-Specific Language Model Pretraining for Biomedical Natural Language Processing](https://mlsanity.com/paper/2007.15779/) (2020)
- [STaR: Bootstrapping Reasoning With Reasoning](https://mlsanity.com/paper/2203.14465/) (2022)
- [AlphaEvolve: A coding agent for scientific and algorithmic discovery](https://mlsanity.com/paper/2506.13131/) (2025)
- [Large Language Model based Multi-Agents: A Survey of Progress and Challenges](https://mlsanity.com/paper/2402.01680/) (2024)
- [Siren's Song in the AI Ocean: A Survey on Hallucination in Large Language Models](https://mlsanity.com/paper/2309.01219/) (2023)
- [BrowseComp: A Simple Yet Challenging Benchmark for Browsing Agents](https://mlsanity.com/paper/2504.12516/) (2025)
- [ClinicalBERT: Modeling Clinical Notes and Predicting Hospital Readmission](https://mlsanity.com/paper/1904.05342/) (2019)
- [MLE-bench: Evaluating Machine Learning Agents on Machine Learning Engineering](https://mlsanity.com/paper/2410.07095/) (2024)
- [Agent Laboratory: Using LLM Agents as Research Assistants](https://mlsanity.com/paper/2501.04227/) (2025)
- [The AI Scientist-v2: Workshop-Level Automated Scientific Discovery via Agentic Tree Search](https://mlsanity.com/paper/2504.08066/) (2025)
- [Accelerating scientific discovery with Co-Scientist](https://mlsanity.com/paper/2502.18864/) (2025)
- [Detecting Pretraining Data from Large Language Models](https://mlsanity.com/paper/2310.16789/) (2023)
- [Can LLMs Generate Novel Research Ideas? A Large-Scale Human Study with 100+ NLP Researchers](https://mlsanity.com/paper/2409.04109/) (2024)
- [PaperBench: Evaluating AI's Ability to Replicate AI Research](https://mlsanity.com/paper/2504.01848/) (2025)

## Built on by (most cited first, 15 of 15)

- [From AI for Science to Agentic Science: A Survey on Autonomous Scientific Discovery](https://mlsanity.com/paper/2508.14111/) (2025)
- [DeepScientist: Advancing Frontier-Pushing Scientific Findings Progressively](https://mlsanity.com/paper/2509.26603/) (2025)
- [AutoFigure: Generating and Refining Publication-Ready Scientific Illustrations](https://mlsanity.com/paper/2602.03828/) (2026)
- [AutoResearch AI: Towards AI-Powered Research Automation for Scientific Discovery](https://mlsanity.com/paper/2605.23204/) (2026)
- [InnoEval: On Research Idea Evaluation as a Knowledge-Grounded, Multi-Perspective Reasoning Problem](https://mlsanity.com/paper/2602.14367/) (2026)
- [Towards autonomous quantum physics research using LLM agents with access to intelligent tools](https://mlsanity.com/paper/2511.11752/) (2025)
- [Principle-Evolvable Scientific Discovery via Uncertainty Minimization](https://mlsanity.com/paper/2602.06448/) (2026)
- [Improving Coherence and Persistence in Agentic AI for System Optimization](https://mlsanity.com/paper/2603.21321/) (2026)
- [Human Cognition in Machines: A Unified Perspective of World Models](https://mlsanity.com/paper/2604.16592/) (2026)
- [What Do Evolutionary Coding Agents Evolve?](https://mlsanity.com/paper/2605.20086/) (2026)
- [Overview of the NLPCC 2026 Shared Task 11: Agent-Based Experiment Reproduction from Scientific Papers](https://mlsanity.com/paper/2609.11117/) (2026)
- [Playing ZendoWorld: Challenging AI Agents on Active Visual Concept Induction](https://mlsanity.com/paper/2607.08233/) (2026)
- [CLINB: A Climate Intelligence Benchmark for Foundational Models](https://mlsanity.com/paper/2511.11597/) (2025)
- [Position: AI Agents in Scientific Teams Should Be Studied as Human-Agent Systems](https://mlsanity.com/paper/2608.14667/) (2026)
- [How Is Automated Research Evaluated? A Survey of Benchmarks and Evaluation Practices](https://mlsanity.com/paper/2610.11877/) (2026)

## Abstract (arXiv)

The emergence of large language models (LLMs) is propelling automated scientific discovery to the next level, with LLM-based Artificial Intelligence (AI) Scientist systems now taking the lead in scientific research. Several influential works have already appeared in the field of AI Scientist systems, with AI-generated research papers having been accepted at the ICLR 2025 workshop, suggesting that a human-level AI Scientist capable of uncovering phenomena previously unknown to humans, may soon become a reality. In this survey, we focus on the central question: How far are AI scientists from changing the world and reshaping the scientific research paradigm? To answer this question, we provide a prospect-driven review that comprehensively analyzes the current achievements of AI Scientist systems, identifying key bottlenecks and the critical components required for the emergence of a scientific agent capable of producing ground-breaking discoveries that solve grand challenges. We hope this survey will contribute to a clearer understanding of limitations of current AI Scientist systems, showing where we are, what is missing, and what the ultimate goals for scientific AI should be.