# Enabling Few-Shot Alzheimer's Disease Diagnosis on Biomarker Data with Tabular LLMs

arXiv: https://arxiv.org/abs/2507.23227 · HTML: https://mlsanity.com/paper/2507.23227/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 18 of its 39 references that are in the map.
- First posted on arXiv 31 Jul 2025.

## Builds on (most cited first, 18 of 18)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [Qwen2.5-Coder Technical Report](https://mlsanity.com/paper/2409.12186/) (2024)
- [Vision-Language Models for Vision Tasks: A Survey](https://mlsanity.com/paper/2304.00685/) (2023)
- [TabPFN: A Transformer That Solves Small Tabular Classification Problems in a Second](https://mlsanity.com/paper/2207.01848/) (2022)
- [Transformers Can Do Bayesian Inference](https://mlsanity.com/paper/2112.10510/) (2021)
- [When Do Neural Nets Outperform Boosted Trees on Tabular Data?](https://mlsanity.com/paper/2305.02997/) (2023)
- [What Algorithms can Transformers Learn? A Study in Length Generalization](https://mlsanity.com/paper/2310.16028/) (2023)
- [Chain-of-Table: Evolving Tables in the Reasoning Chain for Table Understanding](https://mlsanity.com/paper/2401.04398/) (2024)
- [Large Language Models(LLMs) on Tabular Data: Prediction, Generation, and Understanding -- A Survey](https://mlsanity.com/paper/2402.17944/) (2024)
- [TableBench: A Comprehensive and Complex Benchmark for Table Question Answering](https://mlsanity.com/paper/2408.09174/) (2024)
- [Large Language Models Can Automatically Engineer Features for Few-Shot Tabular Learning](https://mlsanity.com/paper/2404.09491/) (2024)
- [TableGPT2: A Large Multimodal Model with Tabular Data Integration](https://mlsanity.com/paper/2411.02059/) (2024)
- [TableGPT: Towards Unifying Tables, Nature Language and Commands into One GPT](https://mlsanity.com/paper/2307.08674/) (2023)
- [Retrieval & Fine-Tuning for In-Context Tabular Models](https://mlsanity.com/paper/2406.05207/) (2024)
- [Generative Table Pre-training Empowers Models for Tabular Prediction](https://mlsanity.com/paper/2305.09696/) (2023)
- [DALK: Dynamic Co-Augmentation of LLMs and KG to answer Alzheimer's Disease Questions with Scientific Literature](https://mlsanity.com/paper/2405.04819/) (2024)
- [Knowledge-Driven Feature Selection and Engineering for Genotype Data with Large Language Models](https://mlsanity.com/paper/2410.01795/) (2024)

## Built on by (most cited first, 1 of 1)

- [Tabular LLMs for Interpretable Few-Shot Alzheimer's Disease Prediction with Multimodal Biomedical Data](https://mlsanity.com/paper/2603.17191/) (2026)

## Abstract (arXiv)

Early and accurate diagnosis of Alzheimer's disease (AD), a complex neurodegenerative disorder, requires analysis of heterogeneous biomarkers (e.g., neuroimaging, genetic risk factors, cognitive tests, and cerebrospinal fluid proteins) typically represented in a tabular format. With flexible few-shot reasoning, multimodal integration, and natural-language-based interpretability, large language models (LLMs) offer unprecedented opportunities for prediction with structured biomedical data. We propose a novel framework called TAP-GPT, Tabular Alzheimer's Prediction GPT, that adapts TableGPT2, a multimodal tabular-specialized LLM originally developed for business intelligence tasks, for AD diagnosis using structured biomarker data with small sample sizes. Our approach constructs few-shot tabular prompts using in-context learning examples from structured biomedical data and finetunes TableGPT2 using the parameter-efficient qLoRA adaption for a clinical binary classification task of AD or cognitively normal (CN). The TAP-GPT framework harnesses the powerful tabular understanding ability of TableGPT2 and the encoded prior knowledge of LLMs to outperform more advanced general-purpose LLMs and a tabular foundation model (TFM) developed for prediction tasks. To our knowledge, this is the first application of LLMs to the prediction task using tabular biomarker data, paving the way for future LLM-driven multi-agent frameworks in biomedical informatics.