# FedCVD++: Communication-Efficient Federated Learning for Cardiovascular Risk Prediction with Parametric and Non-Parametric Model Optimization

arXiv: https://arxiv.org/abs/2507.22963 · HTML: https://mlsanity.com/paper/2507.22963/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 41 references that are in the map.
- First posted on arXiv 30 Jul 2025.

## Builds on (most cited first, 13 of 13)

- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [A Unified Approach to Interpreting Model Predictions](https://mlsanity.com/paper/1705.07874/) (2017)
- [Advances and Open Problems in Federated Learning](https://mlsanity.com/paper/1912.04977/) (2019)
- [Federated Learning: Challenges, Methods, and Future Directions](https://mlsanity.com/paper/1908.07873/) (2019)
- [On the Convergence of FedAvg on Non-IID Data](https://mlsanity.com/paper/1907.02189/) (2019)
- [Towards Federated Learning at Scale: System Design](https://mlsanity.com/paper/1902.01046/) (2019)
- [TensorFlow: Large-Scale Machine Learning on Heterogeneous Distributed Systems](https://mlsanity.com/paper/1603.04467/) (2016)
- [SecureBoost: A Lossless Federated Learning Framework](https://mlsanity.com/paper/1901.08755/) (2019)
- [Privacy Preserving Vertical Federated Learning for Tree-based Models](https://mlsanity.com/paper/2008.06170/) (2020)
- [Patient Clustering Improves Efficiency of Federated Machine Learning to predict mortality and hospital stay time using distributed Electronic Medical Records](https://mlsanity.com/paper/1903.09296/) (2019)
- [Federated Uncertainty-Aware Learning for Distributed Hospital EHR Data](https://mlsanity.com/paper/1910.12191/) (2019)
- [Federated and Differentially Private Learning for Electronic Health Records](https://mlsanity.com/paper/1911.05861/) (2019)
- [Preserving Patient Privacy while Training a Predictive Model of In-hospital Mortality](https://mlsanity.com/paper/1912.00354/) (2019)

## Abstract (arXiv)

Cardiovascular diseases (CVD) cause over 17 million deaths annually worldwide, highlighting the urgent need for privacy-preserving predictive systems. We introduce FedCVD++, an enhanced federated learning (FL) framework that integrates both parametric models (logistic regression, SVM, neural networks) and non-parametric models (Random Forest, XGBoost) for coronary heart disease risk prediction. To address key FL challenges, we propose: (1) tree-subset sampling that reduces Random Forest communication overhead by 70%, (2) XGBoost-based feature extraction enabling lightweight federated ensembles, and (3) federated SMOTE synchronization for resolving cross-institutional class imbalance. Evaluated on the Framingham dataset (4,238 records), FedCVD++ achieves state-of-the-art results: federated XGBoost (F1 = 0.80) surpasses its centralized counterpart (F1 = 0.78), and federated Random Forest (F1 = 0.81) matches non-federated performance. Additionally, our communication-efficient strategies reduce bandwidth consumption by 3.2X while preserving 95% accuracy. Compared to existing FL frameworks, FedCVD++ delivers up to 15% higher F1-scores and superior scalability for multi-institutional deployment. This work represents the first practical integration of non-parametric models into federated healthcare systems, providing a privacy-preserving solution validated under real-world clinical constraints.