# Learning from Heterogeneous Structural MRI via Collaborative Domain Adaptation for Late-Life Depression Assessment

arXiv: https://arxiv.org/abs/2507.22321 · HTML: https://mlsanity.com/paper/2507.22321/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 42 of its 92 references that are in the map.
- First posted on arXiv 30 Jul 2025.

## Builds on (most cited first, 30 of 42)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Training data-efficient image transformers & distillation through attention](https://mlsanity.com/paper/2012.12877/) (2020)
- [Unsupervised Domain Adaptation by Backpropagation](https://mlsanity.com/paper/1409.7495/) (2014)
- [TransUNet: Transformers Make Strong Encoders for Medical Image Segmentation](https://mlsanity.com/paper/2102.04306/) (2021)
- [MixMatch: A Holistic Approach to Semi-Supervised Learning](https://mlsanity.com/paper/1905.02249/) (2019)
- [Learning Transferable Features with Deep Adaptation Networks](https://mlsanity.com/paper/1502.02791/) (2015)
- [Adversarial Discriminative Domain Adaptation](https://mlsanity.com/paper/1702.05464/) (2017)
- [Deep CORAL: Correlation Alignment for Deep Domain Adaptation](https://mlsanity.com/paper/1607.01719/) (2016)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Maximum Classifier Discrepancy for Unsupervised Domain Adaptation](https://mlsanity.com/paper/1712.02560/) (2017)
- [ADVENT: Adversarial Entropy Minimization for Domain Adaptation in Semantic Segmentation](https://mlsanity.com/paper/1811.12833/) (2018)
- [MONAI: An open-source framework for deep learning in healthcare](https://mlsanity.com/paper/2211.02701/) (2022)
- [Self-Challenging Improves Cross-Domain Generalization](https://mlsanity.com/paper/2007.02454/) (2020)
- [Adversarial Domain Adaptation with Domain Mixup](https://mlsanity.com/paper/1912.01805/) (2019)
- [A DIRT-T Approach to Unsupervised Domain Adaptation](https://mlsanity.com/paper/1802.08735/) (2018)
- [Multi-Adversarial Domain Adaptation](https://mlsanity.com/paper/1809.02176/) (2018)
- [TorchIO: A Python library for efficient loading, preprocessing, augmentation and patch-based sampling of medical images in deep learning](https://mlsanity.com/paper/2003.04696/) (2020)
- [Source Data-absent Unsupervised Domain Adaptation through Hypothesis Transfer and Labeling Transfer](https://mlsanity.com/paper/2012.07297/) (2020)
- [Unsupervised Domain Adaptation via Structurally Regularized Deep Clustering](https://mlsanity.com/paper/2003.08607/) (2020)
- [Towards Discriminability and Diversity: Batch Nuclear-norm Maximization under Label Insufficient Situations](https://mlsanity.com/paper/2003.12237/) (2020)
- [Unsupervised domain adaptation in brain lesion segmentation with adversarial networks](https://mlsanity.com/paper/1612.08894/) (2016)
- [Deep Subdomain Adaptation Network for Image Classification](https://mlsanity.com/paper/2106.09388/) (2021)
- [Convolutional Neural Networks for Classification of Alzheimer's Disease: Overview and Reproducible Evaluation](https://mlsanity.com/paper/1904.07773/) (2019)
- [Scatter Component Analysis: A Unified Framework for Domain Adaptation and Domain Generalization](https://mlsanity.com/paper/1510.04373/) (2015)
- [Unsupervised domain adaptation for medical imaging segmentation with self-ensembling](https://mlsanity.com/paper/1811.06042/) (2018)
- [Deep Learning Methods for Parallel Magnetic Resonance Image Reconstruction](https://mlsanity.com/paper/1904.01112/) (2019)
- [Transfer Learning for Domain Adaptation in MRI: Application in Brain Lesion Segmentation](https://mlsanity.com/paper/1702.07841/) (2017)
- [Unsupervised Cross-Modality Domain Adaptation of ConvNets for Biomedical Image Segmentations with Adversarial Loss](https://mlsanity.com/paper/1804.10916/) (2018)

## Abstract (arXiv)

Accurate identification of late-life depression (LLD) using structural brain MRI is essential for monitoring disease progression and facilitating timely intervention. However, existing learning-based approaches for LLD detection are often constrained by limited sample sizes (e.g., tens), which poses significant challenges for reliable model training and generalization. Although incorporating auxiliary datasets can expand the training set, substantial domain heterogeneity, such as differences in imaging protocols, scanner hardware, and population demographics, often undermines cross-domain transferability. To address this issue, we propose a Collaborative Domain Adaptation (CDA) framework for LLD detection using T1-weighted MRIs. The CDA leverages a Vision Transformer (ViT) to capture global anatomical context and a Convolutional Neural Network (CNN) to extract local structural features, with each branch comprising an encoder and a classifier. The CDA framework consists of three stages: (a) supervised training on labeled source data, (b) self-supervised target feature adaptation and (c) collaborative training on unlabeled target data. We first train ViT and CNN on source data, followed by self-supervised target feature adaptation by minimizing the discrepancy between classifier outputs from two branches to make the categorical boundary clearer. The collaborative training stage employs pseudo-labeled and augmented target-domain MRIs, enforcing prediction consistency under strong and weak augmentation to enhance domain robustness and generalization. Extensive experiments conducted on multi-site T1-weighted MRI data demonstrate that the CDA consistently outperforms state-of-the-art unsupervised domain adaptation methods.