# Compression Strategies for Efficient Multimodal LLMs in Medical Contexts

arXiv: https://arxiv.org/abs/2507.21976 · HTML: https://mlsanity.com/paper/2507.21976/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Visual token pruning and efficiency, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 11 of its 17 references that are in the map.
- First posted on arXiv 29 Jul 2025.

## Placed in

- Multimodal LLMs / vision-language models / [Visual token pruning and efficiency](https://mlsanity.com/mllm/visual-token-pruning-and-efficiency/)

## Builds on (most cited first, 11 of 11)

- [Visual Instruction Tuning](https://mlsanity.com/paper/2304.08485/) (2023)
- [QLoRA: Efficient Finetuning of Quantized LLMs](https://mlsanity.com/paper/2305.14314/) (2023)
- [Learning both Weights and Connections for Efficient Neural Networks](https://mlsanity.com/paper/1506.02626/) (2015)
- [MiniLM: Deep Self-Attention Distillation for Task-Agnostic Compression of Pre-Trained Transformers](https://mlsanity.com/paper/2002.10957/) (2020)
- [AWQ: Activation-aware Weight Quantization for LLM Compression and Acceleration](https://mlsanity.com/paper/2306.00978/) (2023)
- [LLM.int8(): 8-bit Matrix Multiplication for Transformers at Scale](https://mlsanity.com/paper/2208.07339/) (2022)
- [LLM-Pruner: On the Structural Pruning of Large Language Models](https://mlsanity.com/paper/2305.11627/) (2023)
- [ShortGPT: Layers in Large Language Models are More Redundant Than You Expect](https://mlsanity.com/paper/2403.03853/) (2024)
- [LLM-QAT: Data-Free Quantization Aware Training for Large Language Models](https://mlsanity.com/paper/2305.17888/) (2023)
- [Multimodal Large Language Models: A Survey](https://mlsanity.com/paper/2311.13165/) (2023)
- [Shortened LLaMA: Depth Pruning for Large Language Models with Comparison of Retraining Methods](https://mlsanity.com/paper/2402.02834/) (2024)

## Built on by (most cited first, 1 of 1)

- [INTERLACE: Interleaved Layer Pruning and Efficient Adaptation in Large Vision-Language Models](https://mlsanity.com/paper/2511.19676/) (2025)

## Abstract (arXiv)

Multimodal Large Language Models (MLLMs) hold huge potential for usage in the medical domain, but their computational costs necessitate efficient compression techniques. This paper evaluates the impact of structural pruning and activation-aware quantization on a fine-tuned LLAVA model for medical applications. We propose a novel layer selection method for pruning, analyze different quantization techniques, and assess the performance trade-offs in a prune-SFT-quantize pipeline. Our proposed method enables MLLMs with 7B parameters to run within 4 GB of VRAM, reducing memory usage by 70% while achieving 4% higher model performance compared to traditional pruning and quantization techniques in the same compression ratio.