# Knowledge Regularized Negative Feature Tuning of Vision-Language Models for Out-of-Distribution Detection

arXiv: https://arxiv.org/abs/2507.19847 · HTML: https://mlsanity.com/paper/2507.19847/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Prompt learning and adaptation of CLIP, one of 16 directions in Multimodal LLMs / vision-language models.
- Builds on 40 of its 72 references that are in the map.
- First posted on arXiv 26 Jul 2025.

## Placed in

- Multimodal LLMs / vision-language models / [Prompt learning and adaptation of CLIP](https://mlsanity.com/mllm/prompt-learning-and-adaptation-of-clip/)

## Builds on (most cited first, 30 of 40)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [Learning to Prompt for Vision-Language Models](https://mlsanity.com/paper/2109.01134/) (2021)
- [Describing Textures in the Wild](https://mlsanity.com/paper/1311.3618/) (2013)
- [Do ImageNet Classifiers Generalize to ImageNet?](https://mlsanity.com/paper/1902.10811/) (2019)
- [A Simple Unified Framework for Detecting Out-of-Distribution Samples and Adversarial Attacks](https://mlsanity.com/paper/1807.03888/) (2018)
- [Natural Adversarial Examples](https://mlsanity.com/paper/1907.07174/) (2019)
- [Enhancing The Reliability of Out-of-distribution Image Detection in Neural Networks](https://mlsanity.com/paper/1706.02690/) (2017)
- [Energy-based Out-of-distribution Detection](https://mlsanity.com/paper/2010.03759/) (2020)
- [CLIP-Adapter: Better Vision-Language Models with Feature Adapters](https://mlsanity.com/paper/2110.04544/) (2021)
- [Learning Robust Global Representations by Penalizing Local Predictive Power](https://mlsanity.com/paper/1905.13549/) (2019)
- [Deep Anomaly Detection with Outlier Exposure](https://mlsanity.com/paper/1812.04606/) (2018)
- [Out-of-Distribution Detection with Deep Nearest Neighbors](https://mlsanity.com/paper/2204.06507/) (2022)
- [ReAct: Out-of-distribution Detection With Rectified Activations](https://mlsanity.com/paper/2111.12797/) (2021)
- [Likelihood Ratios for Out-of-Distribution Detection](https://mlsanity.com/paper/1906.02845/) (2019)
- [On the Importance of Gradients for Detecting Distributional Shifts in the Wild](https://mlsanity.com/paper/2110.00218/) (2021)
- [Pretrained Transformers Improve Out-of-Distribution Robustness](https://mlsanity.com/paper/2004.06100/) (2020)
- [Scaling & Shifting Your Features: A New Baseline for Efficient Model Tuning](https://mlsanity.com/paper/2210.08823/) (2022)
- [Exploring the Limits of Out-of-Distribution Detection](https://mlsanity.com/paper/2106.03004/) (2021)
- [OpenOOD: Benchmarking Generalized Out-of-Distribution Detection](https://mlsanity.com/paper/2210.07242/) (2022)
- [Mitigating Neural Network Overconfidence with Logit Normalization](https://mlsanity.com/paper/2205.09310/) (2022)
- [Learning Confidence for Out-of-Distribution Detection in Neural Networks](https://mlsanity.com/paper/1802.04865/) (2018)
- [MOS: Towards Scaling Out-of-distribution Detection for Large Semantic Space](https://mlsanity.com/paper/2105.01879/) (2021)
- [Delving into Out-of-Distribution Detection with Vision-Language Representations](https://mlsanity.com/paper/2211.13445/) (2022)
- [A Simple Fix to Mahalanobis Distance for Improving Near-OOD Detection](https://mlsanity.com/paper/2106.09022/) (2021)
- [Zero-Shot Out-of-Distribution Detection Based on the Pre-trained Model CLIP](https://mlsanity.com/paper/2109.02748/) (2021)
- [Latent Space Autoregression for Novelty Detection](https://mlsanity.com/paper/1807.01653/) (2018)
- [Unsupervised Out-of-Distribution Detection by Maximum Classifier Discrepancy](https://mlsanity.com/paper/1908.04951/) (2019)

## Built on by (most cited first, 4 of 4)

- [MedSynapse-V: Bridging Visual Perception and Clinical Intuition via Latent Memory Evolution](https://mlsanity.com/paper/2604.26283/) (2026)
- [MIS-HCC: Hierarchical Channel Clustering for Efficient Medical Image Segmentation](https://mlsanity.com/paper/2607.17329/) (2026)
- [Dual Distribution Estimation for Zero-shot Noisy Test-Time Adaptation with VLMs](https://mlsanity.com/paper/2606.25758/) (2026)
- [MMOOC: A Comprehensive Benchmark for Out-of-Context Evaluation in Multimodal Large Language Models](https://mlsanity.com/paper/2607.27637/) (2026)

## Abstract (arXiv)

Out-of-distribution (OOD) detection is crucial for building reliable machine learning models. Although negative prompt tuning has enhanced the OOD detection capabilities of vision-language models, these tuned models often suffer from reduced generalization performance on unseen classes and styles. To address this challenge, we propose a novel method called Knowledge Regularized Negative Feature Tuning (KR-NFT), which integrates an innovative adaptation architecture termed Negative Feature Tuning (NFT) and a corresponding knowledge-regularization (KR) optimization strategy. Specifically, NFT applies distribution-aware transformations to pre-trained text features, effectively separating positive and negative features into distinct spaces. This separation maximizes the distinction between in-distribution (ID) and OOD images. Additionally, we introduce image-conditional learnable factors through a lightweight meta-network, enabling dynamic adaptation to individual images and mitigating sensitivity to class and style shifts. Compared to traditional negative prompt tuning, NFT demonstrates superior efficiency and scalability. To optimize this adaptation architecture, the KR optimization strategy is designed to enhance the discrimination between ID and OOD sets while mitigating pre-trained knowledge forgetting. This enhances OOD detection performance on trained ID classes while simultaneously improving OOD detection on unseen ID datasets. Notably, when trained with few-shot samples from ImageNet dataset, KR-NFT not only improves ID classification accuracy and OOD detection but also significantly reduces the FPR95 by 5.44% under an unexplored generalization setting with unseen ID categories. Codes can be found at hrefhttps://github.com/ZhuWenjie98/KRNFT.