# Joint Holistic and Lesion Controllable Mammogram Synthesis via Gated Conditional Diffusion Model

arXiv: https://arxiv.org/abs/2507.19201 · HTML: https://mlsanity.com/paper/2507.19201/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 24 of its 40 references that are in the map.
- First posted on arXiv 25 Jul 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 24 of 24)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [Zero-1-to-3: Zero-shot One Image to 3D Object](https://mlsanity.com/paper/2303.11328/) (2023)
- [T2I-Adapter: Learning Adapters to Dig out More Controllable Ability for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.08453/) (2023)
- [Semantic Image Synthesis with Spatially-Adaptive Normalization](https://mlsanity.com/paper/1903.07291/) (2019)
- [High-Resolution Image Synthesis and Semantic Manipulation with Conditional GANs](https://mlsanity.com/paper/1711.11585/) (2017)
- [Encoding in Style: a StyleGAN Encoder for Image-to-Image Translation](https://mlsanity.com/paper/2008.00951/) (2020)
- [Medical SAM 2: Segment medical images as video via Segment Anything Model 2](https://mlsanity.com/paper/2408.00874/) (2024)
- [VinDr-Mammo: A large-scale benchmark dataset for computer-aided diagnosis in full-field digital mammography](https://mlsanity.com/paper/2203.11205/) (2022)
- [Annotation-efficient deep learning for automatic medical image segmentation](https://mlsanity.com/paper/2012.04885/) (2020)
- [Anatomically-Controllable Medical Image Generation with Segmentation-Guided Diffusion Models](https://mlsanity.com/paper/2402.05210/) (2024)
- [VTGAN: Semi-supervised Retinal Image Synthesis and Disease Prediction using Vision Transformers](https://mlsanity.com/paper/2104.06757/) (2021)
- [PyMIC: A deep learning toolkit for annotation-efficient medical image segmentation](https://mlsanity.com/paper/2208.09350/) (2022)
- [Evaluating the Performance of StyleGAN2-ADA on Medical Images](https://mlsanity.com/paper/2210.03786/) (2022)
- [MAM-E: Mammographic synthetic image generation with diffusion models](https://mlsanity.com/paper/2311.09822/) (2023)
- [XReal: Realistic Anatomy and Pathology-Aware X-ray Generation via Controllable Diffusion Model](https://mlsanity.com/paper/2403.09240/) (2024)
- [Dual-view Correlation Hybrid Attention Network for Robust Holistic Mammogram Classification](https://mlsanity.com/paper/2306.10676/) (2023)
- [RadiomicsFill-Mammo: Synthetic Mammogram Mass Manipulation with Radiomics Features](https://mlsanity.com/paper/2407.05683/) (2024)
- [RetinaLogos: Fine-Grained Synthesis of High-Resolution Retinal Images Through Captions](https://mlsanity.com/paper/2505.12887/) (2025)

## Built on by (most cited first, 1 of 1)

- [Bidirectional Mammogram View Translation with Column-Aware and Implicit 3D Conditional Diffusion](https://mlsanity.com/paper/2510.04947/) (2025)

## Abstract (arXiv)

Mammography is the most commonly used imaging modality for breast cancer screening, driving an increasing demand for deep-learning techniques to support large-scale analysis. However, the development of accurate and robust methods is often limited by insufficient data availability and a lack of diversity in lesion characteristics. While generative models offer a promising solution for data synthesis, current approaches often fail to adequately emphasize lesion-specific features and their relationships with surrounding tissues. In this paper, we propose Gated Conditional Diffusion Model (GCDM), a novel framework designed to jointly synthesize holistic mammogram images and localized lesions. GCDM is built upon a latent denoising diffusion framework, where the noised latent image is concatenated with a soft mask embedding that represents breast, lesion, and their transitional regions, ensuring anatomical coherence between them during the denoising process. To further emphasize lesion-specific features, GCDM incorporates a gated conditioning branch that guides the denoising process by dynamically selecting and fusing the most relevant radiomic and geometric properties of lesions, effectively capturing their interplay. Experimental results demonstrate that GCDM achieves precise control over small lesion areas while enhancing the realism and diversity of synthesized mammograms. These advancements position GCDM as a promising tool for clinical applications in mammogram synthesis. Our code is available at https://github.com/lixinHUST/Gated-Conditional-Diffusion-Model/