# SP-Mamba: Spatial-Perception State Space Model for Unsupervised Medical Anomaly Detection

arXiv: https://arxiv.org/abs/2507.19076 · HTML: https://mlsanity.com/paper/2507.19076/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 17 of its 27 references that are in the map.
- First posted on arXiv 25 Jul 2025.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 17 of 17)

- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [PaDiM: a Patch Distribution Modeling Framework for Anomaly Detection and Localization](https://mlsanity.com/paper/2011.08785/) (2020)
- [Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery](https://mlsanity.com/paper/1703.05921/) (2017)
- [CutPaste: Self-Supervised Learning for Anomaly Detection and Localization](https://mlsanity.com/paper/2104.04015/) (2021)
- [Multiresolution Knowledge Distillation for Anomaly Detection](https://mlsanity.com/paper/2011.11108/) (2020)
- [PANDA: Adapting Pretrained Features for Anomaly Detection and Segmentation](https://mlsanity.com/paper/2010.05903/) (2020)
- [DeSTSeg: Segmentation Guided Denoising Student-Teacher for Anomaly Detection](https://mlsanity.com/paper/2211.11317/) (2022)
- [Deep Learning for Medical Anomaly Detection -- A Survey](https://mlsanity.com/paper/2012.02364/) (2020)
- [MambaIRv2: Attentive State Space Restoration](https://mlsanity.com/paper/2411.15269/) (2024)
- [VmambaIR: Visual State Space Model for Image Restoration](https://mlsanity.com/paper/2403.11423/) (2024)
- [BMAD: Benchmarks for Medical Anomaly Detection](https://mlsanity.com/paper/2306.11876/) (2023)
- [Transferable Visual Words: Exploiting the Semantics of Anatomical Patterns for Self-supervised Learning](https://mlsanity.com/paper/2102.10680/) (2021)
- [Deep One-Class Classification via Interpolated Gaussian Descriptor](https://mlsanity.com/paper/2101.10043/) (2021)
- [DiAD: A Diffusion-based Framework for Multi-class Anomaly Detection](https://mlsanity.com/paper/2312.06607/) (2023)
- [Implicit field learning for unsupervised anomaly detection in medical images](https://mlsanity.com/paper/2106.05214/) (2021)
- [Exploiting Structural Consistency of Chest Anatomy for Unsupervised Anomaly Detection in Radiography Images](https://mlsanity.com/paper/2403.08689/) (2024)

## Abstract (arXiv)

Radiography imaging protocols target on specific anatomical regions, resulting in highly consistent images with recurrent structural patterns across patients. Recent advances in medical anomaly detection have demonstrated the effectiveness of CNN- and transformer-based approaches. However, CNNs exhibit limitations in capturing long-range dependencies, while transformers suffer from quadratic computational complexity. In contrast, Mamba-based models, leveraging superior long-range modeling, structural feature extraction, and linear computational efficiency, have emerged as a promising alternative. To capitalize on the inherent structural regularity of medical images, this study introduces SP-Mamba, a spatial-perception Mamba framework for unsupervised medical anomaly detection. The window-sliding prototype learning and Circular-Hilbert scanning-based Mamba are introduced to better exploit consistent anatomical patterns and leverage spatial information for medical anomaly detection. Furthermore, we excavate the concentration and contrast characteristics of anomaly maps for improving anomaly detection. Extensive experiments on three diverse medical anomaly detection benchmarks confirm the proposed method's state-of-the-art performance, validating its efficacy and robustness. The code is available at https://github.com/Ray-RuiPan/SP-Mamba.