# A Self-training Framework for Semi-supervised Pulmonary Vessel Segmentation and Its Application in COPD

arXiv: https://arxiv.org/abs/2507.19074 · HTML: https://mlsanity.com/paper/2507.19074/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 20 of its 61 references that are in the map.
- First posted on arXiv 25 Jul 2025.

## Builds on (most cited first, 20 of 20)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [V-Net: Fully Convolutional Neural Networks for Volumetric Medical Image Segmentation](https://mlsanity.com/paper/1606.04797/) (2016)
- [3D U-Net: Learning Dense Volumetric Segmentation from Sparse Annotation](https://mlsanity.com/paper/1606.06650/) (2016)
- [Diffusion Models: A Comprehensive Survey of Methods and Applications](https://mlsanity.com/paper/2209.00796/) (2022)
- [Diffusion Models in Vision: A Survey](https://mlsanity.com/paper/2209.04747/) (2022)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [Self-Supervised Pre-Training of Swin Transformers for 3D Medical Image Analysis](https://mlsanity.com/paper/2111.14791/) (2021)
- [ST++: Make Self-training Work Better for Semi-supervised Semantic Segmentation](https://mlsanity.com/paper/2106.05095/) (2021)
- [DS-TransUNet:Dual Swin Transformer U-Net for Medical Image Segmentation](https://mlsanity.com/paper/2106.06716/) (2021)
- [AUC Maximization in the Era of Big Data and AI: A Survey](https://mlsanity.com/paper/2203.15046/) (2022)
- [Multi-Task Attention-Based Semi-Supervised Learning for Medical Image Segmentation](https://mlsanity.com/paper/1907.12303/) (2019)
- [SAM3D: Segment Anything Model in Volumetric Medical Images](https://mlsanity.com/paper/2309.03493/) (2023)
- [Learning Tubule-Sensitive CNNs for Pulmonary Airway and Artery-Vein Segmentation in CT](https://mlsanity.com/paper/2012.05767/) (2020)
- [NaviAirway: a Bronchiole-sensitive Deep Learning-based Airway Segmentation Pipeline](https://mlsanity.com/paper/2203.04294/) (2022)
- [Pulmonary Vessel Segmentation based on Orthogonal Fused U-Net++ of Chest CT Images](https://mlsanity.com/paper/2107.01502/) (2021)
- [Dual-scale Enhanced and Cross-generative Consistency Learning for Semi-supervised Medical Image Segmentation](https://mlsanity.com/paper/2312.16039/) (2023)
- [Leveraging Labelled Data Knowledge: A Cooperative Rectification Learning Network for Semi-supervised 3D Medical Image Segmentation](https://mlsanity.com/paper/2502.11456/) (2025)

## Abstract (arXiv)

Background: It is fundamental for accurate segmentation and quantification of the pulmonary vessel, particularly smaller vessels, from computed tomography (CT) images in chronic obstructive pulmonary disease (COPD) patients. Objective: The aim of this study was to segment the pulmonary vasculature using a semi-supervised method. Methods: In this study, a self-training framework is proposed by leveraging a teacher-student model for the segmentation of pulmonary vessels. First, the high-quality annotations are acquired in the in-house data by an interactive way. Then, the model is trained in the semi-supervised way. A fully supervised model is trained on a small set of labeled CT images, yielding the teacher model. Following this, the teacher model is used to generate pseudo-labels for the unlabeled CT images, from which reliable ones are selected based on a certain strategy. The training of the student model involves these reliable pseudo-labels. This training process is iteratively repeated until an optimal performance is achieved. Results: Extensive experiments are performed on non-enhanced CT scans of 125 COPD patients. Quantitative and qualitative analyses demonstrate that the proposed method, Semi2, significantly improves the precision of vessel segmentation by 2.3%, achieving a precision of 90.3%. Further, quantitative analysis is conducted in the pulmonary vessel of COPD, providing insights into the differences in the pulmonary vessel across different severity of the disease. Conclusion: The proposed method can not only improve the performance of pulmonary vascular segmentation, but can also be applied in COPD analysis. The code will be made available at https://github.com/wuyanan513/semi-supervised-learning-for-vessel-segmentation.