# RealDeal: Enhancing Realism and Details in Brain Image Generation via Image-to-Image Diffusion Models

arXiv: https://arxiv.org/abs/2507.18830 · HTML: https://mlsanity.com/paper/2507.18830/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 17 of its 26 references that are in the map.
- First posted on arXiv 24 Jul 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 17 of 17)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Image Super-Resolution via Iterative Refinement](https://mlsanity.com/paper/2104.07636/) (2021)
- [Palette: Image-to-Image Diffusion Models](https://mlsanity.com/paper/2111.05826/) (2021)
- [WaveGrad: Estimating Gradients for Waveform Generation](https://mlsanity.com/paper/2009.00713/) (2020)
- [Reliable Fidelity and Diversity Metrics for Generative Models](https://mlsanity.com/paper/2002.09797/) (2020)
- [Brain Imaging Generation with Latent Diffusion Models](https://mlsanity.com/paper/2209.07162/) (2022)
- [Patch Diffusion: Faster and More Data-Efficient Training of Diffusion Models](https://mlsanity.com/paper/2304.12526/) (2023)
- [WDM: 3D Wavelet Diffusion Models for High-Resolution Medical Image Synthesis](https://mlsanity.com/paper/2402.19043/) (2024)
- [Patched Denoising Diffusion Models For High-Resolution Image Synthesis](https://mlsanity.com/paper/2308.01316/) (2023)
- [Memory-Efficient 3D Denoising Diffusion Models for Medical Image Processing](https://mlsanity.com/paper/2303.15288/) (2023)
- [BiomedJourney: Counterfactual Biomedical Image Generation by Instruction-Learning from Multimodal Patient Journeys](https://mlsanity.com/paper/2310.10765/) (2023)
- [Denoising Diffusion Models for 3D Healthy Brain Tissue Inpainting](https://mlsanity.com/paper/2403.14499/) (2024)
- [NASDM: Nuclei-Aware Semantic Histopathology Image Generation Using Diffusion Models](https://mlsanity.com/paper/2303.11477/) (2023)
- [Measuring Feature Dependency of Neural Networks by Collapsing Feature Dimensions in the Data Manifold](https://mlsanity.com/paper/2404.12341/) (2024)
- [MedIL: Implicit Latent Spaces for Generating Heterogeneous Medical Images at Arbitrary Resolutions](https://mlsanity.com/paper/2504.09322/) (2025)

## Built on by (most cited first, 1 of 1)

- [Evaluating the Safety of Deep Learning-Based Brain MRI Reconstruction](https://mlsanity.com/paper/2608.28714/) (2026)

## Abstract (arXiv)

We propose image-to-image diffusion models that are designed to enhance the realism and details of generated brain images by introducing sharp edges, fine textures, subtle anatomical features, and imaging noise. Generative models have been widely adopted in the biomedical domain, especially in image generation applications. Latent diffusion models achieve state-of-the-art results in generating brain MRIs. However, due to latent compression, generated images from these models are overly smooth, lacking fine anatomical structures and scan acquisition noise that are typically seen in real images. This work formulates the realism enhancing and detail adding process as image-to-image diffusion models, which refines the quality of LDM-generated images. We employ commonly used metrics like FID and LPIPS for image realism assessment. Furthermore, we introduce new metrics to demonstrate the realism of images generated by RealDeal in terms of image noise distribution, sharpness, and texture.