# A High Magnifications Histopathology Image Dataset for Oral Squamous Cell Carcinoma Diagnosis and Prognosis

arXiv: https://arxiv.org/abs/2507.16360 · HTML: https://mlsanity.com/paper/2507.16360/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 18 of its 53 references that are in the map.
- First posted on arXiv 22 Jul 2025.

## Builds on (most cited first, 18 of 18)

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- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Layer Normalization](https://mlsanity.com/paper/1607.06450/) (2016)
- [Swin Transformer V2: Scaling Up Capacity and Resolution](https://mlsanity.com/paper/2111.09883/) (2021)
- [Grad-CAM++: Improved Visual Explanations for Deep Convolutional Networks](https://mlsanity.com/paper/1710.11063/) (2017)
- [iBOT: Image BERT Pre-Training with Online Tokenizer](https://mlsanity.com/paper/2111.07832/) (2021)
- [GradNorm: Gradient Normalization for Adaptive Loss Balancing in Deep Multitask Networks](https://mlsanity.com/paper/1711.02257/) (2017)
- [Multi-Task Learning as Multi-Objective Optimization](https://mlsanity.com/paper/1810.04650/) (2018)
- [Which Tasks Should Be Learned Together in Multi-task Learning?](https://mlsanity.com/paper/1905.07553/) (2019)
- [Multi-Task Learning with Deep Neural Networks: A Survey](https://mlsanity.com/paper/2009.09796/) (2020)
- [Scaling Vision Transformers to Gigapixel Images via Hierarchical Self-Supervised Learning](https://mlsanity.com/paper/2206.02647/) (2022)
- [Efficient Low-rank Multimodal Fusion with Modality-Specific Factors](https://mlsanity.com/paper/1806.00064/) (2018)
- [Benchmarking Self-Supervised Learning on Diverse Pathology Datasets](https://mlsanity.com/paper/2212.04690/) (2022)
- [Hibou: A Family of Foundational Vision Transformers for Pathology](https://mlsanity.com/paper/2406.05074/) (2024)
- [Shapley Values-enabled Progressive Pseudo Bag Augmentation for Whole Slide Image Classification](https://mlsanity.com/paper/2312.05490/) (2023)

## Built on by (most cited first, 1 of 1)

- [OralAgent: Integrating Reasoning, Tools, and Knowledge for Interactive Dental Image Analysis](https://mlsanity.com/paper/2605.27378/) (2026)

## Abstract (arXiv)

Oral Squamous Cell Carcinoma (OSCC) is a prevalent and aggressive malignancy where deep learning-based computer-aided diagnosis and prognosis can enhance clinical assessments.However, existing publicly available OSCC datasets often suffer from limited patient cohorts and a restricted focus on either diagnostic or prognostic tasks, limiting the development of comprehensive and generalizable models. To bridge this gap, we introduce Multi-OSCC, a new histopathology image dataset comprising 1,325 OSCC patients, integrating both diagnostic and prognostic information to expand existing public resources. Each patient is represented by six high resolution histopathology images captured at x200, x400, and x1000 magnifications-two per magnification-covering both the core and edge tumor regions.The Multi-OSCC dataset is richly annotated for six critical clinical tasks: recurrence prediction (REC), lymph node metastasis (LNM), tumor differentiation (TD), tumor invasion (TI), cancer embolus (CE), and perineural invasion (PI). To benchmark this dataset, we systematically evaluate the impact of different visual encoders, multi-image fusion techniques, stain normalization, and multi-task learning frameworks. Our analysis yields several key insights: (1) The top-performing models achieve excellent results, with an Area Under the Curve (AUC) of 94.72% for REC and 81.23% for TD, while all tasks surpass 70% AUC; (2) Stain normalization benefits diagnostic tasks but negatively affects recurrence prediction; (3) Multi-task learning incurs a 3.34% average AUC degradation compared to single-task models in our multi-task benchmark, underscoring the challenge of balancing multiple tasks in our dataset. To accelerate future research, we publicly release the Multi-OSCC dataset and baseline models at https://github.com/guanjinquan/OSCC-PathologyImageDataset.