# DeSamba: Decoupled Spectral Adaptive Framework for 3D Multi-Sequence MRI Lesion Classification

arXiv: https://arxiv.org/abs/2507.15487 · HTML: https://mlsanity.com/paper/2507.15487/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 15 of its 28 references that are in the map.
- First posted on arXiv 21 Jul 2025.

## Builds on (most cited first, 15 of 15)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Grad-CAM: Visual Explanations from Deep Networks via Gradient-based Localization](https://mlsanity.com/paper/1610.02391/) (2016)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [EfficientNet: Rethinking Model Scaling for Convolutional Neural Networks](https://mlsanity.com/paper/1905.11946/) (2019)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Aggregated Residual Transformations for Deep Neural Networks](https://mlsanity.com/paper/1611.05431/) (2016)
- [Swin Transformer V2: Scaling Up Capacity and Resolution](https://mlsanity.com/paper/2111.09883/) (2021)
- [ConvNeXt V2: Co-designing and Scaling ConvNets with Masked Autoencoders](https://mlsanity.com/paper/2301.00808/) (2023)
- [FNet: Mixing Tokens with Fourier Transforms](https://mlsanity.com/paper/2105.03824/) (2021)
- [Med3D: Transfer Learning for 3D Medical Image Analysis](https://mlsanity.com/paper/1904.00625/) (2019)
- [MambaOut: Do We Really Need Mamba for Vision?](https://mlsanity.com/paper/2405.07992/) (2024)
- [3D Deep Learning on Medical Images: A Review](https://mlsanity.com/paper/2004.00218/) (2020)
- [A Hybrid Frequency-domain/Image-domain Deep Network for Magnetic Resonance Image Reconstruction](https://mlsanity.com/paper/1810.12473/) (2018)

## Abstract (arXiv)

Magnetic Resonance Imaging (MRI) sequences provide rich spatial and frequency domain information, which is crucial for accurate lesion classification in medical imaging. However, effectively integrating multi-sequence MRI data for robust 3D lesion classification remains a challenge. In this paper, we propose DeSamba (Decoupled Spectral Adaptive Network and Mamba-Based Model), a novel framework designed to extract decoupled representations and adaptively fuse spatial and spectral features for lesion classification. DeSamba introduces a Decoupled Representation Learning Module (DRLM) that decouples features from different MRI sequences through self-reconstruction and cross-reconstruction, and a Spectral Adaptive Modulation Block (SAMB) within the proposed SAMNet, enabling dynamic fusion of spectral and spatial information based on lesion characteristics. We evaluate DeSamba on two clinically relevant 3D datasets. On a six-class spinal metastasis dataset (n=1,448), DeSamba achieves 62.10% Top-1 accuracy, 63.62% F1-score, 87.71% AUC, and 93.55% Top-3 accuracy on an external validation set (n=372), outperforming all state-of-the-art (SOTA) baselines. On a spondylitis dataset (n=251) involving a challenging binary classification task, DeSamba achieves 70.00%/64.52% accuracy and 74.75/73.88 AUC on internal and external validation sets, respectively. Ablation studies demonstrate that both DRLM and SAMB significantly contribute to overall performance, with over 10% relative improvement compared to the baseline. Our results highlight the potential of DeSamba as a generalizable and effective solution for 3D lesion classification in multi-sequence medical imaging.