# Personalized 4D Whole Heart Geometry Reconstruction from Cine MRI for Cardiac Digital Twins

arXiv: https://arxiv.org/abs/2507.15203 · HTML: https://mlsanity.com/paper/2507.15203/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 20 references that are in the map.
- First posted on arXiv 21 Jul 2025.

## Builds on (most cited first, 8 of 8)

- [A Deep-Learning Approach For Direct Whole-Heart Mesh Reconstruction](https://mlsanity.com/paper/2102.07899/) (2021)
- [Towards Enabling Cardiac Digital Twins of Myocardial Infarction Using Deep Computational Models for Inverse Inference](https://mlsanity.com/paper/2307.04421/) (2023)
- [DeepRecon: Joint 2D Cardiac Segmentation and 3D Volume Reconstruction via A Structure-Specific Generative Method](https://mlsanity.com/paper/2206.07163/) (2022)
- [Multi-class point cloud completion networks for 3D cardiac anatomy reconstruction from cine magnetic resonance images](https://mlsanity.com/paper/2307.08535/) (2023)
- [4D Myocardium Reconstruction with Decoupled Motion and Shape Model](https://mlsanity.com/paper/2308.14083/) (2023)
- [Neural Deformable Models for 3D Bi-Ventricular Heart Shape Reconstruction and Modeling from 2D Sparse Cardiac Magnetic Resonance Imaging](https://mlsanity.com/paper/2307.07693/) (2023)
- [3D High-Resolution Cardiac Segmentation Reconstruction from 2D Views using Conditional Variational Autoencoders](https://mlsanity.com/paper/1902.11000/) (2019)
- [MedTet: An Online Motion Model for 4D Heart Reconstruction](https://mlsanity.com/paper/2412.02589/) (2024)

## Abstract (arXiv)

Cardiac digital twins (CDTs) provide personalized in-silico cardiac representations and hold great potential for precision medicine in cardiology. However, whole-heart CDT models that simulate the full organ-scale electromechanics of all four heart chambers remain limited. In this work, we propose a weakly supervised learning model to reconstruct 4D (3D+t) heart mesh directly from multi-view 2D cardiac cine MRIs. This is achieved by learning a self-supervised mapping between cine MRIs and 4D cardiac meshes, enabling the generation of personalized heart models that closely correspond to input cine MRIs. The resulting 4D heart meshes can facilitate the automatic extraction of key cardiac variables, including ejection fraction and dynamic chamber volume changes with high temporal resolution. It demonstrates the feasibility of inferring personalized 4D heart models from cardiac MRIs, paving the way for an efficient CDT platform for precision medicine. The code will be publicly released once the manuscript is accepted.