# OpenBreastUS: Benchmarking Neural Operators for Wave Imaging Using Breast Ultrasound Computed Tomography

arXiv: https://arxiv.org/abs/2507.15035 · HTML: https://mlsanity.com/paper/2507.15035/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 29 references that are in the map.
- First posted on arXiv 20 Jul 2025.

## Builds on (most cited first, 14 of 14)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Fourier Neural Operator for Parametric Partial Differential Equations](https://mlsanity.com/paper/2010.08895/) (2020)
- [DeepONet: Learning nonlinear operators for identifying differential equations based on the universal approximation theorem of operators](https://mlsanity.com/paper/1910.03193/) (2019)
- [Neural Operator: Graph Kernel Network for Partial Differential Equations](https://mlsanity.com/paper/2003.03485/) (2020)
- [PDEBENCH: An Extensive Benchmark for Scientific Machine Learning](https://mlsanity.com/paper/2210.07182/) (2022)
- [U-FNO -- An enhanced Fourier neural operator-based deep-learning model for multiphase flow](https://mlsanity.com/paper/2109.03697/) (2021)
- [Adaptive Fourier Neural Operators: Efficient Token Mixers for Transformers](https://mlsanity.com/paper/2111.13587/) (2021)
- [Neural Inverse Operators for Solving PDE Inverse Problems](https://mlsanity.com/paper/2301.11167/) (2023)
- [Fourier-DeepONet: Fourier-enhanced deep operator networks for full waveform inversion with improved accuracy, generalizability, and robustness](https://mlsanity.com/paper/2305.17289/) (2023)
- [OpenFWI: Large-Scale Multi-Structural Benchmark Datasets for Seismic Full Waveform Inversion](https://mlsanity.com/paper/2111.02926/) (2021)
- [MgNO: Efficient Parameterization of Linear Operators via Multigrid](https://mlsanity.com/paper/2310.19809/) (2023)
- [InversionNet3D: Efficient and Scalable Learning for 3D Full Waveform Inversion](https://mlsanity.com/paper/2103.14158/) (2021)
- [Spatial response identification enables robust experimental ultrasound computed tomography](https://mlsanity.com/paper/2103.10722/) (2021)
- [Neural Born Series Operator for Biomedical Ultrasound Computed Tomography](https://mlsanity.com/paper/2312.15575/) (2023)

## Built on by (most cited first, 2 of 2)

- [Starter-Iterator Neural Operator: A Unified Architecture for High-Fidelity Forward and Inverse PDE Problems](https://mlsanity.com/paper/2606.18305/) (2026)
- [McMg: A Learned Phase-Space Multi-channel Multigrid Preconditioner for Helmholtz Equation](https://mlsanity.com/paper/2606.30495/) (2026)

## Abstract (arXiv)

Accurate and efficient simulation of wave equations is crucial in computational wave imaging applications, such as ultrasound computed tomography (USCT), which reconstructs tissue material properties from observed scattered waves. Traditional numerical solvers for wave equations are computationally intensive and often unstable, limiting their practical applications for quasi-real-time image reconstruction. Neural operators offer an innovative approach by accelerating PDE solving using neural networks; however, their effectiveness in realistic imaging is limited because existing datasets oversimplify real-world complexity. In this paper, we present OpenBreastUS, a large-scale wave equation dataset designed to bridge the gap between theoretical equations and practical imaging applications. OpenBreastUS includes 8,000 anatomically realistic human breast phantoms and over 16 million frequency-domain wave simulations using real USCT configurations. It enables a comprehensive benchmarking of popular neural operators for both forward simulation and inverse imaging tasks, allowing analysis of their performance, scalability, and generalization capabilities. By offering a realistic and extensive dataset, OpenBreastUS not only serves as a platform for developing innovative neural PDE solvers but also facilitates their deployment in real-world medical imaging problems. For the first time, we demonstrate efficient in vivo imaging of the human breast using neural operator solvers.