# Paired Image Generation with Diffusion-Guided Diffusion Models

arXiv: https://arxiv.org/abs/2507.14833 · HTML: https://mlsanity.com/paper/2507.14833/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 15 of its 18 references that are in the map.
- First posted on arXiv 20 Jul 2025.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 15 of 15)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Classifier-Free Diffusion Guidance](https://mlsanity.com/paper/2207.12598/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models](https://mlsanity.com/paper/2112.10741/) (2021)
- [Diffusion Models for Medical Image Analysis: A Comprehensive Survey](https://mlsanity.com/paper/2211.07804/) (2022)
- [More Control for Free! Image Synthesis with Semantic Diffusion Guidance](https://mlsanity.com/paper/2112.05744/) (2021)
- [Improving Sample Quality of Diffusion Models Using Self-Attention Guidance](https://mlsanity.com/paper/2210.00939/) (2022)
- [DDP: Diffusion Model for Dense Visual Prediction](https://mlsanity.com/paper/2303.17559/) (2023)
- [MAISI: Medical AI for Synthetic Imaging](https://mlsanity.com/paper/2409.11169/) (2024)
- [Anatomically-Controllable Medical Image Generation with Segmentation-Guided Diffusion Models](https://mlsanity.com/paper/2402.05210/) (2024)
- [Semi- and Weakly-Supervised Learning for Mammogram Mass Segmentation with Limited Annotations](https://mlsanity.com/paper/2403.09315/) (2024)

## Built on by (most cited first, 1 of 1)

- [UniTriGen: Unified Triplet Generation of Aligned Visible-Infrared-Label for Few-Shot RGB-T Semantic Segmentation](https://mlsanity.com/paper/2605.14626/) (2026)

## Abstract (arXiv)

The segmentation of mass lesions in digital breast tomosynthesis (DBT) images is very significant for the early screening of breast cancer. However, the high-density breast tissue often leads to high concealment of the mass lesions, which makes manual annotation difficult and time-consuming. As a result, there is a lack of annotated data for model training. Diffusion models are commonly used for data augmentation, but the existing methods face two challenges. First, due to the high concealment of lesions, it is difficult for the model to learn the features of the lesion area. This leads to the low generation quality of the lesion areas, thus limiting the quality of the generated images. Second, existing methods can only generate images and cannot generate corresponding annotations, which restricts the usability of the generated images in supervised training. In this work, we propose a paired image generation method. The method does not require external conditions and can achieve the generation of paired images by training an extra diffusion guider for the conditional diffusion model. During the experimental phase, we generated paired DBT slices and mass lesion masks. Then, we incorporated them into the supervised training process of the mass lesion segmentation task. The experimental results show that our method can improve the generation quality without external conditions. Moreover, it contributes to alleviating the shortage of annotated data, thus enhancing the performance of downstream tasks. The source code is available at https://github.com/zhanghx1320/PIG.